...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Early glial responses in murine models of multiple sclerosis.
【24h】

Early glial responses in murine models of multiple sclerosis.

机译：多发性硬化小鼠模型中的早期神经胶质反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Investigations of functional interactions among axons and glia over the last decade have revealed the extent and complexity of glial-neuronal and glial-glial communication during development, adult function and recovery from injury. These data have profound implications for the understanding of central nervous system (CNS) disorders, which until recently, have been classified as either neuronal or glial diseases. Re-evaluation of the pathological processes in a number of conditions has clearly shown involvement of both neurons and glia in early pathology. In multiple sclerosis (MS), the myelin sheath has traditionally been regarded as the primary target. However, recent evidence has clearly demonstrated axonal damage in new lesions. We have addressed the question of the role of axonal pathology in early MS by using well-characterized murine models for the relapsing-remitting (RR) or the primary progressive (PP) forms of the disease. We performed a histopathological survey of the CNS, following induction of the disease, to determine the timing of appearance, as well as the development of lesions. Then we analysed the relationship between inflammation, demyelination and axonal damage together with responses from astrocytes and microglia in each model from the earliest evidence of inflammation. We found that axonal damage begins well ahead of the appearance of motor symptoms. Pathology appears to be more closely related to the degree of inflammation than to demyelination. We also show that early astrocyte responses and the degree of axonal loss are markedly different in the two models and relate to the severity of pathology. These data support the now widely accepted hypothesis that axonal damage begins early in the disease process, but also suggest modulation of axonal loss and disease progression by the astrocytic response.
机译：在过去的十年中，对轴突和神经胶质之间的功能相互作用的研究表明，在发育，成年功能和损伤恢复期间，神经胶质-神经元和神经胶质-神经胶质的交流程度和复杂性。这些数据对了解中枢神经系统（CNS）疾病具有深远的意义，直到最近，这些疾病仍被归类为神经元或神经胶质疾病。在许多情况下对病理过程的重新评估清楚地表明了神经元和神经胶质均参与了早期病理。在多发性硬化症（MS）中，髓鞘通常被视为主要靶标。但是，最近的证据清楚地表明了新病变中的轴突损伤。我们已经通过使用特征明确的鼠模型对疾病的复发-缓解（RR）或原发进行性（PP）形式解决了轴索病理在早期MS中的作用。诱发疾病后，我们对CNS进行了组织病理学调查，以确定出现的时间以及病变的发展。然后，我们从最早的炎症证据中分析了每个模型中炎症，脱髓鞘和轴突损伤之间的关系，以及星形胶质细胞和小胶质细胞的反应。我们发现轴突损伤早于运动症状出现之前就开始了。病理似乎与炎症程度比与脱髓鞘更紧密相关。我们还表明，在两种模型中，早期星形胶质细胞反应和轴突丧失程度明显不同，并且与病理的严重程度有关。这些数据支持了目前被广泛接受的假说，即轴突损伤在疾病过程的早期开始，但也暗示了星形胶质细胞反应调节轴突丧失和疾病进展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号