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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Inducible and constitutive transcription factor NF-kappa B-like DNA binding activities in rat brain cells cultured in vitro.
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Inducible and constitutive transcription factor NF-kappa B-like DNA binding activities in rat brain cells cultured in vitro.

机译：体外培养的大鼠脑细胞中的诱导型和组成型转录因子NF-κB样DNA结合活性。

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摘要

Description of constitutive and inducible transcription factors in brain cells is a prerequisite for understanding phenomena of long-term neuronal plasticity. In this report we report that basal levels of NF-kappa B-like transcription factor DNA binding activity (measured by electrophoretic mobility shift assay) are observed in two kinds of cultured rat brain cells, namely neurons of fetal cerebral hemispheres and astroglia derived from newborn brains. In the latter culture, phorbol ester induces additional forms of DNA binding activity, whereas L-glutamate fails to do so. In neurons, neither treatment is effective in inducing NF-kappa B-like DNA binding activity over the basal level. These results are in contrast to the fact that L-glutamate in both neurons and glia elevates DNA binding activity of AP-1, another transcription factor. These data, besides describing behavior of NF-kappa B-like DNA binding activities, also provide some evidence that L-glutamate exerts its modulatory functions on neurons and glia through specific transcription factors like AP-1.
机译：描述脑细胞中的组成型和诱导型转录因子是了解长期神经元可塑性现象的前提。在本报告中，我们报道了在两种培养的大鼠脑细胞中观察到了基础水平的NF-κB样转录因子DNA结合活性（通过电泳迁移率迁移法测量），即胎儿脑半球的神经元和新生鼠的星形胶质细胞大脑。在后一种培养物中，佛波酯可诱导其他形式的DNA结合活性，而L-谷氨酸则不能。在神经元中，两种治疗都不能有效诱导基础水平以上的NF-κB样DNA结合活性。这些结果与神经元和神经胶质中的L-谷氨酸提高了另一种转录因子AP-1的DNA结合活性的事实形成对比。这些数据除了描述NF-κB类DNA结合活性的行为外，还提供了一些证据表明L-谷氨酸通过特定的转录因子（如AP-1）对神经元和神经胶质发挥其调节功能。

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