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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Complement factors in adult peripheral nerve: a potential role in energy metabolism.
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Complement factors in adult peripheral nerve: a potential role in energy metabolism.

机译：成人周围神经的补体因子：在能量代谢中的潜在作用。

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摘要

Complement cascade factors are known to play a critical role in myelin clearance after peripheral nerve injury. Here we show that components of both the classical (C1qa, C1qb, C1qc, C2 and C4) and alternative (C3, B and adipsin) pathways are expressed by uninjured peripheral nerve as well. mRNAs of components of the alternative pathway were predominantly found in the peri/epineurium, although factor C3 and factor B were also detected in the endoneurial compartment of adult nerve. Interestingly, adipsin mRNA was detected only in peri/epineurium, while adipsin protein was present in both peri/epineurium and endoneurium. This suggests that adipsin is transported to the endoneurium via the circulation from the peri/epineurium or outside of the nerve. Factor 5 and factor 9, necessary for the formation of the membrane-attack complex, were not detected in any part of the healthy peripheral nerve, which together with the observed presence of negative regulators of complement activation, is likely to prevent damage to the healthy nerve caused by complement activation. By analogy with the known role of complement factors in fat, we propose that local expression of these factors plays a role in the regulation of fatty acid homeostasis in the nerve and, thereby, in energy metabolism cross-talk between different compartments of the peripheral nerve.
机译：已知补体级联因子在周围神经损伤后的髓鞘清除中起关键作用。在这里，我们显示经典路径（C1qa，C1qb，C1qc，C2和C4）和替代路径（C3，B和adipsin）的成分也由未受伤的周围神经表达。尽管在成年神经的神经内膜隔室中也检测到了因子C3和因子B，但主要在周缘/神经外膜中发现了替代途径的成分的mRNA。有趣的是，仅在peri / epineurium中检测到adipsin mRNA，而在peri / epineurium和神经内膜中均存在adipsin蛋白。这表明，己二醛通过循环从周围/神经外膜或神经外转运至神经内膜。在健康的周围神经的任何部分都未检测到形成膜攻击复合物所必需的因子5和因子9，它们与所观察到的补体激活负调节剂一起存在，很可能防止对健康的损害神经由补体激活引起。通过与脂肪中补体因子的已知作用进行类比，我们建议这些因子的局部表达在神经中脂肪酸稳态的调节中起作用，从而在周围神经不同区室之间的能量代谢串扰中起作用。

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