Tolerated nitrite therapy in experimental intracerebral hemorrhage: Rationale of nitrite therapy in a broad range of hyperacute strokes.

Jung KH; Chu K; Lee ST; Kim JM; Park DK; Kim M; Lee SK; Roh JK

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Tolerated nitrite therapy in experimental intracerebral hemorrhage: Rationale of nitrite therapy in a broad range of hyperacute strokes.

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Tolerated nitrite therapy in experimental intracerebral hemorrhage: Rationale of nitrite therapy in a broad range of hyperacute strokes.

机译：实验性脑出血中的亚硝酸盐耐受治疗：广泛的超急性中风亚硝酸盐治疗的原理。

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Nitrite therapy is more effective in cerebral ischemia when administered earlier. It would be beneficial during the hyperacute stages of stroke if the nitrite effect is demonstrated in intracerebral hemorrhage (ICH). When nitrite is injected intravenously 3h after ICH induction in rats, most doses of nitrite provided no beneficial effects on behavioral deficits, brain edema and hematoma volumes. A high dose of nitrite, however, decreased hematoma volume, but not brain edema. Peri-hematomal apoptosis and inflammation were similar between the control and nitrite groups. Nitrite therapy may be considered a therapeutic option in hyperacute stroke because nitrite therapy is tolerated in ICH as well.

机译：提早使用亚硝酸盐疗法对脑缺血更有效。如果在脑出血（ICH）中表现出亚硝酸盐作用，则在卒中的超急性阶段将是有益的。在大鼠ICH诱导后3h静脉内注射亚硝酸盐时，大多数剂量的亚硝酸盐对行为缺陷，脑水肿和血肿量均无有益作用。然而，高剂量的亚硝酸盐可减少血肿量，但不会减少脑水肿。对照组和亚硝酸盐组之间的血肿周围血细胞凋亡和炎症相似。亚硝酸盐疗法可能被认为是超急性中风的一种治疗选择，因为亚硝酸盐疗法在ICH中也可以耐受。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2011年第1期|共5页
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Jung KH; Chu K; Lee ST; Kim JM; Park DK; Kim M; Lee SK; Roh JK;
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正文语种 eng
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1. Tolerated nitrite therapy in experimental intracerebral hemorrhage: Rationale of nitrite therapy in a broad range of hyperacute strokes. [J] . Jung KH, Chu K, Lee ST, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2011,第1期

机译：实验性脑出血中的亚硝酸盐耐受治疗：广泛的超急性中风亚硝酸盐治疗的原理。
2. Broad-band ultraviolet B phototherapy is associated with elevated serum thiobarbituric acid reactive substance and nitrite-nitrate levels in psoriatic patients. [J] . Kilinc Karaarslan I, Girgin Sagin F, Ertam I, Journal of the European Academy of Dermatology and Venereology: JEADV . 2006,第10期

机译：宽带紫外线B光疗与银屑病患者的血清硫代巴比妥酸反应性物质和硝酸亚硝酸盐水平升高有关。
3. Intracerebral hemorrhage: natural history and rationale of ultra-early hemostatic therapy. [J] . Mayer SA Intensive care medicine . 2002,第Suppla2期

机译：脑出血：自然史和超早期止血疗法的原理。
4. Radiomics-based prediction of symptomatic intracerebral hemorrhage before thrombolysis therapy in unenhanced CT imaging [C] . Hui Xu, Wenbing Lyu, Dong Zeng, IEEE Nuclear Science Symposium;Medical Imaging Conference . 2018

机译：未增强CT成像中基于放射学的溶栓治疗前症状性脑出血的预测
5. Transcranial Therapy for Intracerebral Hemorrhage and Other Brain Pathologies Using Histotripsy [D] . Gerhardson, Tyler. 2020

机译：使用组蛋白酶的脑出血和其他脑病变的颅内治疗
6. RBC washing nitrite therapy and anti-heme therapies prevent stored RBC toxicity after trauma-hemorrhage [O] . Ryan Stapley, Cilina Rodriguez, Joo-Yeun Oh, -1

机译：RBC冲洗亚硝酸盐疗法和抗血红素疗法可防止创伤性出血后储存的RBC毒性
7. Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma–hemorrhage [O] . Ryan Stapley, Cilina Rodriguez, Joo-Yeun Oh, 2015

机译：红细胞洗涤，亚硝酸盐治疗和抗血液疗法防止储存的红细胞毒性后创伤后出血

Tolerated nitrite therapy in experimental intracerebral hemorrhage: Rationale of nitrite therapy in a broad range of hyperacute strokes.

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