Scaffold protein Homer 1: Implications for neurological diseases

LuoP.; LiX.; FeiZ.; PoonW.

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Scaffold protein Homer 1: Implications for neurological diseases

机译：支架蛋白荷马1：对神经系统疾病的影响

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Homer proteins are commonly known as scaffold proteins at postsynaptic density. Homer 1 is a widely studied member of the Homer protein family, comprising both synaptic structure and mediating postsynaptic signaling transduction. Both an immediate-early gene encoding a Homer 1 variant and a constitutively expressed Homer 1 variant regulate receptor clustering and trafficking, intracellular calcium homeostasis, and intracellular molecule complex formation. Substantial preclinical investigations have implicated that each of these Homer 1 variants are associated with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, drug-induced addiction, and traumatic brain injury.

机译：荷马蛋白通常被称为突触后密度的支架蛋白。荷马1是荷马蛋白家族的一个广泛研究的成员，既包括突触结构又介导突触后信号转导。编码Homer 1变体的即刻早期基因和组成性表达的Homer 1变体均调节受体簇集和运输，细胞内钙稳态和细胞内分子复合物的形成。大量的临床前研究表明，这些Homer 1变体中的每一种都与许多神经系统疾病的病因有关，例如疼痛，智力低下综合征，阿尔茨海默氏病，精神分裂症，药物引起的成瘾和脑外伤。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2012年第5期|共8页
作者
LuoP.; LiX.; FeiZ.; PoonW.;
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正文语种 eng
中图分类生物化学;
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Addiction; Fragile X syndrome; Homer protein; Metabotropic glutamate receptor; Neuropathic pain; Postsynaptic density; Schizophrenia; Transient receptor potential channel; Traumatic brain injury; X-linked mental retardation;

机译：成瘾;脆性X综合征;荷马蛋白;促代谢型谷氨酸受体;神经性疼痛;突触后密度;精神分裂症;短暂受体电位通道;颅脑外伤;X连锁性智力低下;

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1. Scaffold protein Homer 1: Implications for neurological diseases [J] . LuoP., LiX., FeiZ., Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2012,第5期

机译：支架蛋白荷马1：对神经系统疾病的影响
2. Genome-Wide Approaches to Dissect the Roles of RNA Binding Proteins in Translational Control: Implications for Neurological Diseases [J] . Kapeli Katannya, Yeo Gene Frontiers in Neurogenomics . 2012,第1a2期

机译：全基因组方法来分析RNA结合蛋白在翻译控制中的作用：对神经系统疾病的影响。
3. Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. [J] . Schroder B, Franz B, Hempfling P, Human Genetics . 2001,第3期

机译：ion病毒样蛋白基因（Prnd）内的多态性及其对人类病毒病，阿尔茨海默氏病和其他神经系统疾病的影响。
4. NitroDIGE: A New Method to Investigate the Subproteome of the S-Nitrosylated Proteins in Neurological Diseases [C] . Fanjun Meng, Fan Wei, Siqi Liu, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：Nitrodige：一种研究神经疾病中S-亚硝基蛋白蛋白的亚甲基甲壳的新方法
5. Molecular diagnosis for hereditary neurological diseases in Mali, West Africa: Research and social implications [D] . Meilleur, Katherine G. 2009

机译：西非马里遗传性神经疾病的分子诊断：研究和社会意义
6. Genome-Wide Approaches to Dissect the Roles of RNA Binding Proteins in Translational Control: Implications for Neurological Diseases [O] . Katannya Kapeli, Gene W. Yeo 2012

机译：全基因组方法来分析RNA结合蛋白在翻译控制中的作用：对神经系统疾病的影响。
7. Genome-wide approaches to dissect the roles of RNA binding proteins in translational control: implications for neurological diseases [O] . Katannya eKapeli, Gene eYeo 2012

机译：全基因组方法解剖RNa结合蛋白在转化控制中的作用：对神经系统疾病的影响

Scaffold protein Homer 1: Implications for neurological diseases

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