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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Effects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes.
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Effects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes.

机译：肿瘤坏死因子α对培养的大鼠星形胶质细胞中牛磺酸摄取的影响。

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摘要

Taurine is known to play a major role in volume regulation in astrocytic swelling associated with stroke and brain trauma. Apart from brain edema, the severity of brain injury is related to the levels of inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha). TNFalpha had been shown to be closely associated with brain edema formation since the neutralization of TNFalpha reduced brain edema. Considering taurine has osmoregulatory functions in astrocytes, experiments were performed to study the effects of TNFalpha on taurine uptake in cultured astrocytes. Astrocytes exposed to 20 ng/ml of TNFalpha for 48 h showed a 91% increase in taurine uptake and significant increase was observed after 24 h exposure. This cytokine caused neither significant changes in cell volume nor taurine release. The increased in taurine uptake induced by TNFalpha was unlikely resulted from the modification of Na(+) movement because TNFalpha decreased tyrosine uptake, Na(+)-dependent transport system. In contrast to TNFalpha, interferon-gamma (IFNgamma) did not significantly affect taurine uptake. Taken together, our results did not support a suggestion that TNFalpha affects cell volume regulation via modulating taurine uptake in astrocytes. Increasing lines of evidence have demonstrated that taurine has anti-inflammatory and anti-oxidative effects, these findings therefore suggested that the increase in taurine uptake might be an adaptive response or a tool for astrocytes against oxidative stress.
机译：已知牛磺酸在中风和脑外伤相关的星形细胞肿胀中的体积调节中起主要作用。除脑水肿外，脑损伤的严重程度还与炎性细胞因子的水平有关，例如肿瘤坏死因子α（TNFalpha）。由于TNFα的中和减少了脑水肿，因此已经证明TNFα与脑水肿的形成密切相关。考虑到牛磺酸在星形胶质细胞中具有渗透调节功能，进行了实验以研究TNFα对培养的星形胶质细胞摄取牛磺酸的影响。暴露于20 ng / mlTNFα的星形胶质细胞48小时显示牛磺酸摄取增加91％，暴露24小时后观察到显着增加。该细胞因子既不引起细胞体积的显着变化，也不引起牛磺酸的释放。由TNFα引起的牛磺酸摄取的增加不太可能是由Na（+）运动的修饰引起的，因为TNFalpha降低了酪氨酸的摄取，Na（+）依赖性转运系统。与TNFalpha相比，干扰素-γ（IFNγ）不会显着影响牛磺酸的摄取。两者合计，我们的结果不支持TNFalpha通过调节星形胶质细胞中牛磺酸的摄取影响细胞体积调节的建议。越来越多的证据表明，牛磺酸具有抗炎和抗氧化作用，因此这些发现表明，牛磺酸摄取的增加可能是星形胶质细胞抗氧化应激的适应性反应或工具。

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