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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using alpha-((11)C)methyl-L-tryptophan and positron emission tomography.
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Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using alpha-((11)C)methyl-L-tryptophan and positron emission tomography.

机译：使用α-（（11）C）甲基-L-色氨酸和正电子发射断层扫描技术测量，增加血氧会增加人脑中5-HT合成的指数。

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The main objective of this investigation was to test the hypothesis that brain serotonin (5-HT) synthesis, as measured by trapping of alpha-[(11)C]methyl-L-tryptophan (alpha-MTrp) using positron emission tomography (PET), can be modulated by changes in blood oxygen. The study involved six healthy participants (three male and three female), who breathed a 15% or 60% oxygen mixture starting 15 min before the injection of tracer and continuing during the entire acquisition period. Participants were injected with up to 12m Ci of alpha-MTrp. Two sets of PET images were acquired while the participants were breathing each of the oxygen mixtures and, after reconstruction, all images were converted into brain functional images illustrating the brain trapping constant K(*) (microL/g/min). The K(*) values were obtained for 12 regions of interest outlined on the magnetic resonance images. The K(*) values obtained at high and low blood oxygen content were compared by paired statistics using Tukey's post hoc correction. As there were no difference in plasma tryptophan concentrations, these K(*) values are directly related to regional 5-HT synthesis. The results showed highly significant increases (50% on average) in brain serotonin synthesis (K(*) values) at high (mean value of 223+/-41 mmHg) relative to low (mean value 77.1+/-7.7 mmHg) blood oxygen levels. This suggests that tryptophan hydroxylase is not saturated with oxygen in the living human brain and that increases in blood oxygen can elevate brain serotonin synthesis.
机译：这项研究的主要目的是检验假设通过使用正电子发射断层扫描（PET）捕获α-[（11）C]甲基-L-色氨酸（alpha-MTrp）来测量大脑5-羟色胺（5-HT）合成的假说），可以通过改变血液中的氧气来调节。该研究涉及六名健康参与者（三名男性和三名女性），他们在注射示踪剂前15分钟开始呼吸15％或60％的氧气混合物，并在整个采集期间持续呼吸。参与者被注射了高达12m Ci的alpha-MTrp。在参与者呼吸每种氧气混合物的同时，采集了两组PET图像，重建后，所有图像都转换为说明大脑捕集常数K（*）（microL / g / min）的大脑功能图像。对于磁共振图像上概述的12个感兴趣区域，获得了K（*）值。使用Tukey事后校正通过配对统计比较了在高和低血氧含量下获得的K（*）值。由于血浆色氨酸浓度没有差异，因此这些K（*）值与区域5-HT合成直接相关。结果表明，相对于低（平均血液值77.1 +/- 7.7 mmHg）血液，高（平均血液值223 +/- 41 mmHg）时脑5-羟色胺合成（K（*）值）显着增加（平均50％）氧气含量。这表明色氨酸羟化酶在活的人脑中不会被氧饱和，而血液中氧的增加会提高脑中血清素的合成。

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