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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Rapid modulation of TRH and TRH-like peptide levels in rat brain and peripheral tissues by corticosterone.
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Rapid modulation of TRH and TRH-like peptide levels in rat brain and peripheral tissues by corticosterone.

机译：皮质酮可快速调节大鼠大脑和周围组织中TRH和TRH样肽的水平。

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摘要

Disturbance of glucocorticoid signaling has been implicated in several neuropsychiatric disorders including unipolar and bipolar depression and anxiety induced by maternal deprivation. Antidepressants have been shown to be neuroprotective and able to reverse damage to glia and neurons. Thyrotropin-releasing hormone (TRH) is an endogenous antidepressant that reduces the expression of glycogen synthase kinase-3beta (GSK-3beta), an enzyme that hyperphosphorylates tau and is implicated in bipolar depression, diabetes and Alzheimer's disease. In order to understand the potential role of TRH and TRH-like peptides both as mediators of the depressogenic effects of glucocorticoids and as potential therapeutics for neuropsychiatric disease, 300 g male Sprague-Dawley rats were injected i.p. with 4 mg corticosterone/0.5 ml 50% DMSO+50% ethanol and sacrificed 0, 2, 4 and 8h later. Levels of TRH and TRH-like peptides were measured in various brain regions involved in mood regulation and pancreas and reproductive tissues that mediate the metabolic and reproductive impairments associated with high glucocorticoid levels. Significant increases, ranging from 2- to 12-fold, in TRH or TRH-like peptide levels were observed in almost all brain regions studied at 4h after corticosterone injection. In cerebellum, TRH and TRH-like peptides increased 4-14-fold by 8h. TRH-like peptide levels fell 86-98% at 4h after treatment in testis. TRH, derived only from Leydig cells, was not affected. TRH and TRH-like peptides increased 2-4-fold at 8h in pancreas. TRH and TRH-like peptide concentrations in prostate were not affected by corticosterone up to 8h after injection. The 4h needed to detect a highly significant change in the TRH and TRH-like peptide levels in brain and peripheral tissues is consistent with the mediation of most corticosterone-effects via alterations in gene transcription.
机译：糖皮质激素信号传导的紊乱已经牵涉到几种神经精神疾病，包括单相和双相抑郁和母体剥夺引起的焦虑。已显示抗抑郁药具有神经保护作用，能够逆转对神经胶质和神经元的伤害。促甲状腺激素释放激素（TRH）是一种内源性抗抑郁药，可降低糖原合酶激酶3beta（GSK-3beta）的表达，该酶使tau过度磷酸化，并涉及双相抑郁症，糖尿病和阿尔茨海默氏病。为了了解TRH和TRH样肽既可作为糖皮质激素的降压作用的介质，又可作为神经精神疾病的潜在治疗剂的潜在作用，经腹膜内注射300g雄性Sprague-Dawley大鼠。用4 mg皮质酮/0.5 ml 50％DMSO + 50％乙醇，并在0、2、4和8h后处死。在涉及情绪调节的各个大脑区域以及与高糖皮质激素水平相关的介导代谢和生殖功能障碍的胰腺和生殖组织中，测量了TRH和TRH样肽的水平。注射皮质酮后4h，几乎所有研究的脑区域都观察到TRH或TRH样肽水平显着增加，从2到12倍不等。在小脑中，TRH和TRH样肽在8h时增加4-14倍。治疗后4小时，睾丸中TRH样肽水平下降了86-98％。仅源自Leydig细胞的TRH不受影响。在胰腺中，TRH和TRH样肽在8h增加2-4倍。注射后最多8小时，皮质激素不会影响前列腺中TRH和TRH样肽的浓度。检测大脑和周围组织中TRH和TRH样肽水平的高度显着变化所需的4小时与通过基因转录改变介导的大多数皮质酮效应相一致。

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