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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Alterations in NADPH oxidase expression and blood-brain barrier in bile duct ligation-treated young rats: Effects of melatonin
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Alterations in NADPH oxidase expression and blood-brain barrier in bile duct ligation-treated young rats: Effects of melatonin

机译：胆管结扎治疗的幼鼠中NADPH氧化酶表达和血脑屏障的变化：褪黑素的影响

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摘要

Bile duct ligation (BDL)-treated rats exhibit cholestasis and increased systemic and brain oxidative stress. Activation of NADPH (nicotinamide adenine dinucleotide phosphate) oxidase and disruption of the blood-brain barrier (BBB) are implicated as the pathogenetic mechanisms of brain dysfunction in BDL-treated adult rats. Young rats underwent sham ligation or BDL at day 17 for 2 or 4 weeks. Treatment group rats were administered melatonin between day 17 and 45. We found a progressive increase in prefrontal cortex NADPH-dependent superoxide anion (O2-) production and increased expression of NADPH oxidase subunits in either the prefrontal cortex or the hippocampus in BDL-treated young rats. In addition, expression of intercellular adhesion molecule-1 (ICAM) and tissue plasminogen activator (t-PA) genes were increased in either the prefrontal cortex or the hippocampus. Prefrontal cortex capillary junctional complex proteins expressions including occludin, claudin-5, platelet endothelial cell adhesion molecule-1 and vascular endothelial cadherin were not altered. Melatonin lowered the prefrontal cortex NADPH-dependent O2- production and t-PA gene expression. We conclude that alterations in NADPH oxidase expression and BBB are involved in brain dysfunction in BDL-treated young rats. In addition, melatonin regulates NADPH oxidase activity and t-PA gene expression.
机译：胆管结扎术（BDL）处理的大鼠表现出胆汁淤积以及全身和脑部氧化应激增加。 NADPH（烟酰胺腺嘌呤二核苷酸磷酸）氧化酶的激活和血脑屏障（BBB）的破坏被认为是用BDL治疗的成年大鼠脑功能障碍的发病机制。幼鼠在第17天进行假结扎或BDL治疗2或4周。治疗组大鼠在第17天至第45天之间服用了褪黑激素。我们发现，经BDL治疗的年轻大鼠的额叶前皮质NADPH依赖性超氧阴离子（O2-）产生逐渐增加，NADPH氧化酶亚基的表达增加。大鼠。此外，前额叶皮层或海马中细胞间黏附分子-1（ICAM）和组织纤溶酶原激活物（t-PA）基因的表达增加。前额叶皮层毛细血管连接复合蛋白的表达，包括occludin，claudin-5，血小板内皮细胞粘附分子1和血管内皮钙黏着蛋白没有改变。褪黑素降低了额叶前皮质NADPH依赖性的O2产生和t-PA基因表达。我们得出的结论是，NADPH氧化酶表达和BBB的改变与BDL治疗的幼鼠的脑功能障碍有关。另外，褪黑素调节NADPH氧化酶活性和t-PA基因表达。

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