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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
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Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.

机译：离子型谷氨酸受体拮抗剂对微毒素癫痫发作过程中细胞外谷氨酸和天冬氨酸水平修饰的影响：在自由运动大鼠中的微透析研究。

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Our previous studies have shown a local decrease in glutamate and aspartate levels during seizures, induced by picrotoxin microdialysis in the hippocampus of chronic freely moving rats. In this paper, we study the effect of continuous hippocampal microperfusion of the NMDA, AMPA and kainate glutamate receptor inhibitors 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine (MK-801); 6,7-dinitroquinoxaline-2,3-dione (DNQX), and 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride (GYKI 52466). We also examine the action of L(-)-threo-3-hydroxyaspartic acid (THA), a glutamate and aspartate reuptake blocker, on the modification of extracellular glutamate and aspartate levels induced by picrotoxin, using the microdialysis method in freely moving rats. We found that changes in extracellular hippocampal concentrations in both amino acids are prevented by NMDA, AMPA and kainate receptor inhibitors. Seizures elicited under DNQX also induce a transient increase in aspartate extracellular levels coincident with seizure time. L(-)-threo-3-hydroxyaspartic acid increased the basal extracellular concentrations of both amino acids, but did not prevent the seizure-related decrease. Our results suggest that glutamate, the major neurotransmitter at the synaptic level, may also play an important role in non-synaptic transmission during seizures.
机译：我们以前的研究表明，癫痫发作期间谷氨酸和天冬氨酸水平的局部降低是由慢性自由活动大鼠海马中的微毒素微透析引起的。在本文中，我们研究了连续海马微灌输NMDA，AMPA和氨基甲酸酯谷氨酸受体抑制剂5-甲基-10,11-二氢-5H-二苯并[a，d] cyclohepten-5，10-亚胺（MK- 801）; 6,7-二硝基喹喔啉-2,3-二酮（DNQX）和1-（4-氨基苯基）-4-甲基-7,8-亚甲基二氧基-5H-2,3-苯二氮卓盐酸盐（GYKI 52466）。我们还研究了L（-）-苏-3-羟基天冬氨酸（THA），谷氨酸和天冬氨酸再摄取阻滞剂对微毒素诱导的微毒素诱导的细胞外谷氨酸和天冬氨酸水平修饰的作用，使用微透析方法在自由运动大鼠中进行。我们发现，NMDA，AMPA和海藻酸酯受体抑制剂可防止两种氨基酸的细胞外海马浓度变化。 DNQX引起的癫痫发作还引起与癫痫发作时间一致的天冬氨酸细胞外水平的短暂增加。 L（-）-苏-3-羟基天冬氨酸增加了两种氨基酸的基础细胞外浓​​度，但没有阻止与癫痫发作有关的减少。我们的结果表明，谷氨酸是突触水平的主要神经递质，在癫痫发作期间的非突触传递中也可能起重要作用。

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