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首页> 外文期刊>Neurobiology of learning and memory >Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k
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Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k

机译：通过要求mGluR5信号传导和持续激活p70s6k的机制，环境富集改善了成年幼鼠的学习和记忆能力并增强了其长期增强能力。

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Previous studies from our lab have demonstrated that mild cognitive impairments identified early in life are predictive of cognitive deficits that develop with age, suggesting that enhancements in cognition at an early age can provide a buffer against age-related cognitive decline. Environmental enrichment has been shown to improve learning and memory in the rodent, but the impact of enrichment on synaptic plasticity and the molecular mechanisms behind enrichment are not completely understood. To address these unresolved issues, we have housed 2-month old rats in environmentally enriched (EE), socially enriched (SE), or standard housing (SC) and conducted tests of learning and memory formation at various time intervals. Here we demonstrate that animals that have been exposed to one month of social or environmental enrichment demonstrate enhanced learning and memory relative to standard housed controls. However, we have found that after 4 months EE animals perform better than both SE and SC groups and demonstrate an enhanced hippocampal LTP. Our results demonstrate that this LTP is dependent on mGluR5 signaling, activation of ERK and mTOR signaling cascades, and sustained phosphorylation of p70s6 kinase, thus providing a potential target mechanism for future studies of cognitive enhancement in the rodent. (C) 2015 Elsevier Inc. All rights reserved.
机译：我们实验室以前的研究表明，在生命早期发现的轻度认知障碍可以预测随着年龄增长而出现的认知缺陷，这表明在早期认知能力的增强可以为与年龄相关的认知能力下降提供缓冲。研究表明，环境富集可以改善啮齿动物的学习和记忆能力，但是，富集对突触可塑性和富集背后的分子机制的影响尚不完全清楚。为了解决这些未解决的问题，我们将2个月大的大鼠安置在环境丰富（EE），社会丰富（SE）或标准住房（SC）中，并在不同的时间间隔进行了学习和记忆形成的测试。在这里，我们证明，相对于标准饲养的对照组，暴露于社交或环境丰富一个月的动物表现出增强的学习和记忆。但是，我们发现EE动物在4个月后的表现优于SE和SC组，并且海马LTP增强。我们的结果表明，该LTP依赖于mGluR5信号传导，ERK和mTOR信号传导级联的激活以及p70s6激酶的持续磷酸化，因此为啮齿类动物认知增强的未来研究提供了潜在的靶标机制。 （C）2015 Elsevier Inc.保留所有权利。

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