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首页> 外文期刊>Neurobiology of learning and memory >Chronic stress, cyclic 17beta-estradiol, and daily handling influences on fear conditioning in the female rat.
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Chronic stress, cyclic 17beta-estradiol, and daily handling influences on fear conditioning in the female rat.

机译：慢性应激，环状17β-雌二醇和日常处理会影响雌性大鼠的恐惧状况。

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Chronic stress and estrogens alter many forebrain regions in female rats that affect cognition. In order to investigate how chronic stress and estrogens influence fear learning and memory, we ovariectomized (OVX) female Sprague-Dawley rats and repeatedly injected them (s.c.) with 17beta-estradiol (E, 10 mug/250 g or sesame oil vehicle, VEH). Concurrently, rats were restrained for 6 h/d/21 d (STR) or left undisturbed (CON). Rats were then fear conditioned with 4 tone-footshock pairings and then after 1 h and 24 h delays, given 15 tone extinction trials. Regardless of E treatment, chronic stress (VEH, E) facilitated freezing to tone during acquisition and extinction following a 1h delay, but not during extinction after a 24 h delay. E did not influence freezing to tone during any phase of fear conditioning for either the control or chronically stressed rats, but did influence contextual conditioning that may have been carried predominately by the STR group. In the second experiment, we investigated handling findings from the current study and previous work (Baran, Armstrong, Niren, & Conrad, 2010; Baran, Armstrong, Niren, Hanna, & Conrad, 2009). Female rats remained gonadally-intact since E did not influence tone fear conditioning. Indeed, brief daily handling (1-3 m/d/21 d) facilitated acquisition of fear conditioning in chronically stressed female rats, and either had no effect or slightly attenuated fear conditioning in controls. Thus, chronic stress impacts amygdala-mediated fear learning in both OVX- and gonadally-intact females as found previously in males, with handling significantly influencing these outcomes.
机译：慢性应激和雌激素会改变雌性大鼠许多影响认知的前脑区域。为了研究慢性压力和雌激素如何影响恐惧学习和记忆，我们将卵巢切除的雌性Sprague-Dawley大鼠去卵巢（OVX），并向其反复（sc）注射17beta-雌二醇（E，10杯/ 250克或芝麻油媒介物VEH） ）。同时，大鼠被束缚6 h / d / 21 d（STR）或保持不受干扰（CON）。然后，对大鼠进行4次声调-休克配对，然后进行15次声调灭绝试验，然后在延迟1小时和24小时后进行恐惧调节。不管采用何种E处理，慢性应激（VEH，E）都会在延迟1小时后的采集和灭绝过程中促进冰冻至色调，但在延迟24小时后的灭绝过程中则不会。在对照组或长期处于应激状态的大鼠的恐惧条件调节的任何阶段，E均不影响其冻结至语调，但在STR组中可能影响了情境条件调节。在第二个实验中，我们调查了当前研究和先前工作的处理结果（Baran，Armstrong，Niren和Conrad，2010; Baran，Armstrong，Niren，Hanna和Conrad，2009）。由于E不影响音调恐惧条件，所以雌性大鼠仍保持性腺完整。确实，短暂的每日处理（1-3 m / d / 21 d）促进了长期处于应激状态的雌性大鼠的恐惧条件的获得，并且在对照组中没有影响或略微减轻了恐惧条件。因此，慢性应激会影响先前在男性中发现的，在OVX和性腺完整的女性中杏仁核介导的恐惧学习，并且处理会显着影响这些结果。

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