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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >The role of catecholamines in the prolactin release induced by salsolinol.
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The role of catecholamines in the prolactin release induced by salsolinol.

机译：儿茶酚胺在Salsolinol诱导的催乳激素释放中的作用。

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摘要

Salsolinol (1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline) is an endogenous prolactin releasing agent. Its action can be inhibited by another isoquinoline, 1-methyl-3,4-dihydroisoquinoline (1MeDIQ), which has a strong norepinephrine releasing activity. Salsolinol does not alter the dopamine release in median eminence in vitro, providing evidence for the lack of interaction with presynaptic D2 dopamine receptors. At the same time, lack of norepinephrine transporter abolishes salsolinol's action. Salsolinol decreases tissue level of dopamine and increases norepinephrine to dopamine ratio in organs innervated by the sympathetic nervous system indicating a possible decrease of norepinephrine release. Enzymes of catecholamine synthesis and metabolism are probably also not the site of action of salsolinol. In summary, based upon all of these observations a physiologically relevant interplay might exist between the sympatho-neuronal system and the regulation of prolactin release.
机译：Salsolinol（1,2,3,4-四氢-6,7-二羟基-1-甲基异喹啉）是一种内源性催乳素释放剂。它的作用可以被另一种异喹啉（1-甲基-3,4-二氢异喹啉（1MeDIQ））抑制，该异喹啉具有很强的去甲肾上腺素释放活性。 Salsolinol不会改变体外中位突出中的多巴胺释放，提供了与突触前D2多巴胺受体缺乏相互作用的证据。同时，缺乏去甲肾上腺素转运蛋白消除了沙索林醇的作用。 Salsolinol降低了交感神经系统支配的器官中多巴胺的组织水平，并增加了去甲肾上腺素与多巴胺的比率，表明去甲肾上腺素释放可能降低。儿茶酚胺合成和代谢的酶也可能不是沙丁胺醇的作用部位。总之，基于所有这些观察结果，交感神经系统与催乳素释放的调节之间可能存在生理上相关的相互作用。

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