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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >VEGFR-3/Flt-4 mediates proliferation and chemotaxis in glial precursor cells.
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VEGFR-3/Flt-4 mediates proliferation and chemotaxis in glial precursor cells.

机译：VEGFR-3 / Flt-4介导神经胶质前体细胞的增殖和趋化性。

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摘要

Neuronal and vascular cells share common chemical signals. Vascular endothelial growth factor (VEGF)-C and -D and their receptor VEGFR-3/Flt-4 mediate lymphangiogenesis, but they occur also in the brain. Quantitative RT-PCR of mouse brain tissues and cultivated cells showed that the VEGFR-3 gene is highest transcribed in postnatal brain and in glial precursor cells whereas VEGF-C and -D are variably produced by different neuronal and glial cells. In neurospheres (neural stem cells) VEGFR-3 was induced by differentiation with platelet-derived growth factor (PDGF). In functional studies with an A2B5- and nestin-positive, O4-negative murine glial precursor cell line, VEGF-C and -D stimulated phosphorylation of the kinases Erk1/2; this signal transduction was inhibited by UO126. Both peptides induced the proliferation of glial precursor cells which could be inhibited by UO126. Furthermore, VEGF-D considerably enhanced their migration into an open space in a wound-healing assay. These results show that VEGF-C/-D together with its receptor VEGFR-3 provides an auto-/paracrine growth and chemotactic system for glial precursors in the developing brain.
机译：神经细胞和血管细胞共享共同的化学信号。血管内皮生长因子（VEGF）-C和-D及其受体VEGFR-3 / Flt-4介导淋巴管生成，但它们也存在于大脑中。小鼠脑组织和培养细胞的定量RT-PCR显示，VEGFR-3基因在出生后脑和神经胶质前体细胞中转录最高，而VEGF-C和-D由不同的神经元和神经胶质细胞可变地产生。在神经球（神经干细胞）中，VEGFR-3是通过血小板衍生生长因子（PDGF）分化而诱导的。在利用A2B5-和巢蛋白阳性，O4-阴性鼠神经胶质前体细胞系进行的功能研究中，VEGF-C和-D刺激了激酶Erk1 / 2的磷酸化。该信号转导被UO126抑制。两种肽均诱导了胶质前体细胞的增殖，这可以被UO126抑制。此外，在伤口愈合试验中，VEGF-D显着增强了它们向开放空间的迁移。这些结果表明，VEGF-C / -D及其受体VEGFR-3为发育中的大脑胶质前体提供了自身/旁分泌生长和趋化系统。

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