Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness.

Takemiya T

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness.

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Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness.

机译：由微粒体前列腺素E合酶1产生的前列腺素E2调节清醒的发生和维持。

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This study examined the effect of prostaglandin E(2) (PGE(2)) produced by microsomal prostaglandin E synthase-1 (mPGES-1) on circadian rhythm. Using wild-type mice (WT) and mPGES-1 knockout mice (mPGES-1(-/-)), I recorded and automatically analyzed the natural behavior of mice in home cages for 24h and measured brain levels of PGE(2). The switch to wakefulness was not smooth, and sleepiness and the total duration of sleep were significantly longer in the mPGES-1(-/-) mice. Moreover, the basal concentration of PGE(2) was significantly lower in the mPGES-1(-/-) mice. These findings suggest that PGE(2) produced by mPGES-1 regulates the onset of wakefulness and the maintenance of circadian rhythm.

机译：这项研究检查了微粒体前列腺素E合酶1（mPGES-1）产生的前列腺素E（2）（PGE（2））对昼夜节律的影响。我使用野生型小鼠（WT）和mPGES-1敲除小鼠（mPGES-1（-/-）），记录并自动分析了笼中小鼠的自然行为24h，并测量了PGE（2）的大脑水平。在mPGES-1（-/-）小鼠中，转为清醒并不顺利，并且嗜睡和总睡眠时间明显更长。此外，在mPGES-1（-/-）小鼠中PGE（2）的基础浓度显着降低。这些发现表明，mPGES-1产生的PGE（2）调节清醒的发作和昼夜节律的维持。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2011年第6期|共3页
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Takemiya T;
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中图分类生物化学;
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1. Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness. [J] . Takemiya T Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2011,第6期

机译：由微粒体前列腺素E合酶1产生的前列腺素E2调节清醒的发生和维持。
2. Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production. [J] . Ikeda Matsuo Y, Ikegaya Y, Matsuki N, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2005,第6期

机译：小胶质细胞特异性前列腺素E2合酶1的表达有助于脂多糖诱导的前列腺素E2的产生。
3. Anti-inflammatory properties of prostaglandin E2: Deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice [J] . FrolovA., YangL., DongH., Prostaglandins, Leukotrienes, and Essential Fatty Acids . 2013,第5期

机译：前列腺素E2的抗炎特性：微粒体前列腺素E合酶-1的缺失加剧了小鼠的非免疫性炎性关节炎
4. Synthesis, In Silico Molecular Docking Modeling and Pharmacophore Mapping of (E)-3-(4-Hydroxy-2,6-Dimethoxyphenyl)-1 -Phenylprop-2-en-1 - One as Potential New Inhibitor of Microsomal Prostaglandin E2 Synthase-1 [C] . Pitipat Sanphetchaloemchok, Mohd Fadhlizil Fasihi Mohd Aluwi, Kamal Rullah, Postgraduate Symposium on Industrial Science and Technology . 2020

机译：（E）-3-（4-羟基-2,6-二甲氧基苯基）-1-phenylprop-2-en-1的硅分子对接建模和药效线映射，作为微粒体前列腺素E2合酶的潜在新抑制剂 - 1
5. Regulatory role of prostaglandin E2 in establishment and maintenance of pregnancy in cattle: Molecular and cellular interactions. [D] . Arosh, Joe A. 2004

机译：前列腺素E2在牛的妊娠建立和维持中的调节作用：分子和细胞相互作用。
6. Hyperforin an Anti-Inflammatory Constituent from St. Johns Wort Inhibits Microsomal Prostaglandin E2 Synthase-1 and Suppresses Prostaglandin E2 Formation in vivo [O] . Andreas Koeberle, Antonietta Rossi, Julia Bauer, 2011

机译：Hyperforin是一种来自圣约翰草的抗炎成分抑制微粒体前列腺素E2合酶1并抑制体内前列腺素E2的形成。
7. Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model [O] . David Claveau, Mirna Sirinyan, Jocelyne Guay, 2003

机译：微粒体前列腺素E合成酶-1是在大鼠佐剂诱导的关节炎模型中在环氧酶-2依赖性前列腺素E2产生期间选择性上调的主要末端合成酶
8. Prostaglandin E2 Receptor Expression by Osteoblasts is Modulated by Implant Surface Roughness and Prostaglandin E2 [R] . Campbell, M. M. 2006

机译：成骨细胞的前列腺素E2受体表达受植入物表面粗糙度和前列腺素E2的调节。

Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness.

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