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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >No change in the density of the serotonin1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia.
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No change in the density of the serotonin1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia.

机译：精神分裂症患者背外侧前额叶皮层中5-羟色胺1A受体，5-羟色胺4受体或5-羟色胺转运蛋白的密度没有变化。

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摘要

Changes in serotonin receptors and the serotonin transporter have been reported in the dorsolateral prefrontal cortex from subjects with schizophrenia, an area of the brain thought to be important in the pathology of the illness. To further our understanding on how such changes could play a role in the pathology of the illness, in situ radioligand binding with autoradiography was used to measure the density of the serotonin1A receptor, the serotonin4 receptor and the serotonin transporter in the dorsolateral prefrontal cortex, obtained at autopsy, from 10 schizophrenic and 10 control subjects. The binding of [3H]8-OH-DPAT to serotonin1A receptor, [3H]GR113808 to the 5HT4 receptor and [3H]citalopram to serotonin transporter was not altered in subjects with schizophrenia. significantly, only in tissue from the control subjects was there a relationship between age and the density of the serotonin4 receptor in Brodmann's areas 8 (r = 0.71, P = 0.02) and 10 (r = -0.67, P = 0.03). Importantly, this confounding factor did not influence the comparison of the density of serotonin4 receptor in the tissue from the schizophrenic and control subjects. This study has failed to show a difference in the density of serotonin1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex (Brodmann's areas 8, 9 and 10) from subjects with schizophrenia. These data suggest that not all serotonergic markers are altered in the dorsolateral prefrontal cortex from schizophrenic subjects.
机译：据报道患有精神分裂症的受试者的背外侧前额叶皮层中5-羟色胺受体和5-羟色胺转运蛋白的变化，该区域的大脑在疾病病理学中很重要。为了进一步了解这种变化如何在疾病的病理过程中发挥作用，采用放射自显影结合原位放射配体来测量背外侧前额叶皮层中血清素1A受体，血清素4受体和血清素转运蛋白的密度。进行尸检时，来自10位精神分裂症患者和10位对照受试者。在精神分裂症患者中，[3H] 8-OH-DPAT与5-羟色胺1A受体，[3H] GR113808与5HT4受体和[3H]西酞普兰与5-羟色胺转运蛋白的结合没有改变。显着地，仅在对照受试者的组织中，年龄与布罗德曼地区8（r = 0.71，P = 0.02）和10（r = -0.67，P = 0.03）的血清素4受体密度之间存在相关性。重要的是，该混杂因素并不影响精神分裂症患者和对照组患者血清素4受体密度的比较。这项研究未能显示精神分裂症患者背外侧前额叶皮层（Brodmann病区8、9和10）中血清素1A受体，血清素4受体或血清素转运蛋白的密度存在差异。这些数据表明，并非所有精神分裂症患者的血清素能标记都发生了改变。

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