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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >NMDA modulation of dopamine dynamics is diminished in the aged striatum: an in vivo voltametric study.
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NMDA modulation of dopamine dynamics is diminished in the aged striatum: an in vivo voltametric study.

机译：NMDA对多巴胺动力学的调节在老年纹状体中减弱：一项体内伏安研究。

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摘要

The technique of in vivo voltametry and a paired recording paradigm were employed to study the age-related changes in N-methyl-d-aspartate (NMDA) function in regulating the striatal dopaminergic transmission in male Sprague-Dawley rats. Microinjection of NMDA (100pmol) consistently elicited larger striatal dopamine (DA) overflows from young rats (3-4 months old) than from aged rats (27-28 months old). Furthermore, the rate of clearance (T(c)) of the NMDA-evoked dopamine release was lower in the aged rats. Local application of dopamine evoked reversible electrochemical signals with similar amplitudes in both young and aged rats. However, T(c) was reduced and time course parameters were prolonged in the aged rats. While microejection of NMDA (1pmol) did not induce any dopamine overflow, simultaneous administration of NMDA and K(+) evoked larger dopamine releases than K(+) alone in the young striatum. Concomitant application of NMDA did not potentiate the K(+)-evoked dopamine release in the aged striatum.Taken together, with the reduced dopamine release in response to depolarizing stimuli, our in vivo electrochemical data suggest that age-related changes in NMDA function contribute to the impaired dopaminergic dynamics, including an attenuation of NMDA-evoked dopamine release and a diminished augmentation by K(+) of NMDA-induced dopamine release during the normal aging process.
机译：采用体内伏安法和配对记录范式研究了N-甲基-d-天冬氨酸（NMDA）在调节雄性Sprague-Dawley大鼠纹状体多巴胺能传递中的年龄相关变化。显微注射NMDA（100pmol）始终引起幼鼠（3-4个月大）比老年鼠（27-28个月大）产生更大的纹状体多巴胺（DA）溢出。此外，在老年大鼠中，NMDA引起的多巴胺释放的清除率（T（c））较低。在年轻和老年大鼠中，局部应用多巴胺引起可逆的电化学信号，幅度相似。然而，在老年大鼠中，T（c）降低并且时程参数延长。虽然微注射NMDA（1pmol）不会引起任何多巴胺溢出，但同时给予NMDA和K（+）引起的年轻纹状体比单独使用K（+）引起的多巴胺释放更大。 NMDA的同时使用并没有增强衰老纹状体中K（+）引起的多巴胺的释放，结合去极化刺激引起的多巴胺释放减少，我们的体内电化学数据表明NMDA功能的年龄相关变化有助于多巴胺能动力学受损，包括在正常衰老过程中NMDA诱发的多巴胺释放的减弱和NMDA诱导的多巴胺释放的K（+）的增加减少。

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