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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration.
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BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration.

机译：在胆碱能变性的免疫毒素192 IgG-Saporin大鼠模型中，血清和顶叶皮质中BDNF浓度降低。

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The neurotrophin brain-derived neurotrophic factor (BDNF) has been extensively studied because of its role in survival, differentiation and function of neurons undergoing degeneration in pathological conditions such as cholinergic neurons in Alzheimer's disease (AD). However, despite these evidences, the role of BDNF in these events is still matter of debate because central and peripheral BDNF levels are often found in opposite direction. Another puzzling factor is represented by pharmacological treatments known to cause alterations of BDNF peripheral levels. Thus, a pivotal issue would be to verify whether brain and serum BDNF changes are interconnected as well as the possibility that different stages of cholinergic degeneration are characterized by different changes in BDNF brain and serum levels. With this in mind in this study we used a rat model of cholinergic degeneration based on intracerebroventricular (i.c.v.) injections of 192 IgG-Saporin and measured brain and serum BDNF concentrations by enzyme-linked immunosorbent assay (ELISA) at 3, 7 and 15days from immunotoxin injection. We found that BDNF levels were reduced in parietal cortex and serum of Saporin-treated rats at 15days from lesion. Moreover, a positive correlation between serum and parietal cortex was observed at 15days from lesion. These alterations were not present at the earlier post-operative time points. In conclusion, this study shows that BDNF levels are reduced in a rat model of cholinergic degeneration and suggests that these alterations may occur at later stages. In addition, a positive correlation between serum and parietal cortex changes is observed. Even if the cause for the relationship between BDNF in serum and this brain region is unknown, these data may help to elucidate the significance of peripheral and central BDNF changes in brain pathological conditions.
机译：由于神经营养蛋白脑源性神经营养因子（BDNF）在病理条件下经历退化的神经元（例如胆碱能神经元）的存活，分化和功能中的作用，因此对其进行了广泛的研究。然而，尽管有这些证据，但BDNF在这些事件中的作用仍存在争议，因为中枢和外周BDNF的水平往往是相反的。另一个令人费解的因素是已知引起BDNF周围水平改变的药物治疗。因此，一个关键性的问题将是验证大脑和血清BDNF的变化是否相互关联，以及不同阶段的胆碱能变性以BDNF大脑和血清水平的不同变化为特征的可能性。考虑到这一点，在本研究中，我们使用了基于192 IgG-Saporin的脑室内（icv）注射的胆碱能变性的大鼠模型，并在3、7和15天后通过酶联免疫吸附测定（ELISA）测量了脑和血清BDNF的浓度。免疫毒素注射。我们发现，从病变开始第15天，顶叶皮质和Saporin处理的大鼠血清中BDNF水平降低。此外，从病变开始第15天，血清和顶叶皮层之间存在正相关。这些改变在较早的术后时间点不存在。总而言之，这项研究表明在胆碱能变性的大鼠模型中BDNF水平降低，并表明这些改变可能在以后的阶段发生。另外，观察到血清和顶叶皮层变化之间呈正相关。即使未知血清中BDNF与该大脑区域之间关系的原因，这些数据也可能有助于阐明外周和中枢BDNF变化在脑病理状况中的重要性。

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