Rat brain proteome in morphine dependence.

Bierczynska Krzysik A; Bonar E; Drabik A; Noga M; Suder P; Dylag T; Dubin A; Kotlinska J; Silberring J

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Rat brain proteome in morphine dependence.

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Rat brain proteome in morphine dependence.

机译：大鼠脑蛋白质组中吗啡依赖性。

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The aim of this study was to reveal potential markers associated with drug dependence, using the proteomic approach. Gels containing samples derived from morphine-treated and control animals were compared and analyzed. Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem mass spectrometry, allowed for identification of eleven potential dependence markers, mainly cytoplasmic and mitochondrial enzymes, e.g. proteins that belong to GTPase and GST superfamilies, ATPase, asparaginase or proteasome subunit p27 families.

机译：这项研究的目的是使用蛋白质组学方法揭示与药物依赖性相关的潜在标记。比较和分析了含有衍生自吗啡治疗和对照动物的样品的凝胶。在TCA /丙酮沉淀后，使用蛋白质组学检查，并使用纳米级液相色谱与串联质谱联用，可鉴定出11种潜在的依赖标记，主要是细胞质和线粒体酶，例如属于GTPase和GST超家族，ATPase，天冬酰胺酶或蛋白酶体亚基p27家族的蛋白质。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2006年第4期|共6页
作者
Bierczynska Krzysik A; Bonar E; Drabik A; Noga M; Suder P; Dylag T; Dubin A; Kotlinska J; Silberring J;
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正文语种 eng
中图分类基础医学;
关键词
Morphine; Rattus norvegicus; Proteins; Brain; g lt; 3gt; 吗啡; 蛋白质类; 脑;

机译：Morphine;Rattus norvegicus;Proteins;Brain;g 3;吗啡;蛋白质类;脑;

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1. Rat brain proteome in morphine dependence. [J] . Bierczynska Krzysik A, Bonar E, Drabik A, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2006,第4期

机译：大鼠脑蛋白质组中吗啡依赖性。
2. Some determinants of morphine effects on intracranial self-stimulation in rats: dose, pretreatment time, repeated treatment, and rate dependence. [J] . Altarifi AA, Negus SS Behavioural pharmacology . 2011,第7期

机译：吗啡对大鼠颅内自我刺激的一些决定因素：剂量，预处理时间，重复治疗和速率依赖性。
3. Non-peptidergic OP4 receptor agonist inhibits morphine antinociception but does not influence morphine dependence. [J] . Kotlinska J, Wichmann J, Rafalski P, Neuroreport . 2003,第4期

机译：非肽能OP4受体激动剂抑制吗啡镇痛作用，但不影响吗啡依赖性。
4. Support vector machine classification of multi-channel EEG traces: A new tool to analyze the brain response to morphine treatment [C] . Graversen Carina, Drewes Asbjorn Mohr, Farina Dario 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：支持向量机对多通道脑电图痕迹的分类：分析脑对吗啡治疗反应的新工具
5. Oxidative Stress and Proteomic Studies of Mammalian Models of Age-Related Metabolic Dysfunction in Neurodegenerative Disorders: (1) Upregulation of Pin1 in Alzheimer Mouse Model (2) Analysis of Brain Post-Intranasal Administration of Insulin in Alzheimer and Induced Diabetic Mouse Models (3) Analysis Of Proteome Changes In The Parietal Lobule Of Rhesus Monkey Non-Human Primate Following Resveratrol Supplementation as a Part of a Western-Diet. [D] . Swomley, Aaron Michael. 2017

机译：氧化应激和蛋白质组学研究的神经退行性疾病的年龄相关代谢功能障碍的哺乳动物模型：（1）阿尔茨海默病小鼠模型中Pin1的上调（2）鼻内注射胰岛素对老年性痴呆症小鼠和诱导的糖尿病小鼠模型的分析（3）白藜芦醇补充作为西方饮食的一部分，恒河猴非人类灵长类动物顶叶小叶蛋白质组变化的分析。
6. Antidiuretic effect of morphine in the rat: tolerance and physical dependence. [O] . F Huidobro 1978

机译：吗啡在大鼠中的抗利尿作用：耐受性和身体依赖性。
7. Antidiuretic effect of morphine in the rat: tolerance and physical dependence. [O] . Huidobro, F 1978

机译：吗啡在大鼠中的抗利尿作用：耐受性和身体依赖性。
8. Biochemical Aspects of Alcohol Tolerance and Dependence and Biochemical Aspects of Morphine Tolerance and Physical Dependence. [R] . Brody, T. M. 1976

机译：酒精耐受的生化方面和吗啡耐受和物理依赖的依赖性和生化方面。

Rat brain proteome in morphine dependence.

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