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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Treatment of hypoxic-ischemic encephalopathy in mouse by transplantation of embryonic stem cell-derived cells.
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Treatment of hypoxic-ischemic encephalopathy in mouse by transplantation of embryonic stem cell-derived cells.

机译：通过移植胚胎干细胞衍生的细胞来治疗小鼠缺氧缺血性脑病。

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摘要

A 7-day-old hypoxic-ischemic encephalopathy (HIE) mouse model was used to study the effect of transplantation of embryonic stem (ES) cell-derived cells on the HIE. After the inducement in vitro, the ES cell-derived cells expressed Nestin and MAP-2, rather than GFAP mRNA. After transplantation, ES cell-derived cells can survive, migrate into the injury site, and specifically differentiate into neurons, showing improvement of the learning ability and memory of the HIE mouse at 8 months post-transplantation. The non-grafted HIE mouse brain showed typical pathological changes in the hippocampus and cerebral cortex, where the number of neurons was reduced, while in the cell graft group, number of the neurons increased in the same regions. Although further study is necessary to elucidate the precise mechanisms responsible for this functional recovery, we believe that ES cells have advantages for use as a donor source in HIE.
机译：使用7天大的缺氧缺血性脑病（HIE）小鼠模型研究胚胎干（ES）细胞来源的细胞移植对HIE的影响。体外诱导后，ES细胞来源的细胞表达Nestin和MAP-2，而不是GFAP mRNA。移植后，ES细胞衍生的细胞可以存活，迁移到损伤部位，并特异性分化为神经元，显示出移植后8个月HIE小鼠的学习能力和记忆力得到改善。未移植的HIE小鼠大脑在海马和大脑皮层中表现出典型的病理变化，其中神经元数量减少，而在细胞移植组中，相同区域中的神经元数量增加。尽管有必要进行进一步的研究以阐明造成这种功能恢复的确切机制，但我们认为ES细胞在HIE中作为供体来源具有优势。

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