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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Hydrogen sulfide: a novel signaling molecule in the central nervous system.
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Hydrogen sulfide: a novel signaling molecule in the central nervous system.

机译：硫化氢：中枢神经系统中的新型信号分子。

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摘要

Hydrogen sulfide is an endogenously produced gas in the central nervous system and has been touted as the body's third gaseous signaling molecule after nitric oxide and carbon monoxide. A review of the current understanding of hydrogen sulfide is necessary in view of the current plethora of research in this area. The aim of this review is to present the current understanding of H(2)S as a signaling molecule in the central nervous system (CNS). This objective is achieved by discussing the involvement of H(2)S in the regulation of (1) intracellular signaling molecules such as protein kinase A, receptor tyrosine kinases, mitogen kinases and oxidative stress signaling, (2) ion channels such as calcium (L-type, T-type and intracellular stores), potassium (K(ATP) and small conductance channels) and cystic fibrosis transmembrane conductance regulator chloride channels, (3) the release and function of neurotransmitters such as gamma-aminobutyric acid, N-methyl-D-aspartate, glutamate and catecholamines. The role of H(2)S as an important mediator in a myriad of neural functions inclusive of neuroprotection is also discussed throughout the review.
机译：硫化氢是中枢神经系统中一种内源性产生的气体，被吹捧为人体中继一氧化氮和一氧化碳之后的第三种气体信号分子。鉴于目前在该领域的大量研究，有必要对当前对硫化氢的理解进行回顾。本文的目的是介绍H（2）S作为中枢神经系统（CNS）中的信号分子的当前理解。通过讨论H（2）S在（1）细胞内信号分子（例如蛋白激酶A，受体酪氨酸激酶，促分裂原激酶和氧化应激信号传导），（2）离子通道（例如钙（ L型，T型和细胞内存储），钾（K（ATP）和小电导通道）和囊性纤维化跨膜电导调节剂氯离子通道，（3）诸如γ-氨基丁酸，N- D-天冬氨酸甲酯，谷氨酸和儿茶酚胺。 H（2）S作为重要介体在包括神经保护在内的无数种神经功能中的作用也在整个综述中进行了讨论。

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