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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Parity decreases methamphetamine-induced striatal dopaminergic perturbation.
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Parity decreases methamphetamine-induced striatal dopaminergic perturbation.

机译：奇偶校验减少了甲基苯丙胺引起的纹状体多巴胺能摄动。

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摘要

The role of parity upon methamphetamine-induced neurotoxicity of the striatal dopaminergic system was assessed. Female CD-1 mice either remained nulliparous or underwent one or three complete pregnancies and were designated as the 0, 1 or 3 pregnancy groups. The mice were then treated with a neurotoxic regimen of methamphetamine (MA--40 mg/kg) or its saline vehicle (control) and striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels were measured at 7-days post-MA. Basal levels of striatal DA, DOPAC and the DOPAC/DA ratio were similar among the saline (control) 0, 1 and 3 pregnancy groups. In response to MA, striatal DA and DOPAC were significantly decreased in the 0 and 1 pregnancy as compared with the control group. Mice with 3 pregnancies showed DA and DOPAC levels that did not differ from controls and were significantly greater than the 0 pregnancy group. The DOPAC/DA ratios of the 0 pregnancy group were significantly greater than all other groups (control, 1 and 3 pregnancy) which failed to differ among each other. These results demonstrate that parity decreases MA-induced striatal dopaminergic neurotoxicity, and the degree of this neuroprotection is related to the number of pregnancies experienced.
机译：评估了平价对甲基苯丙胺诱导的纹状体多巴胺能系统神经毒性的作用。雌性CD-1小鼠要么保持未产，要么进行了一到三个完整的怀孕，并被指定为0、1、3怀孕组。然后用甲基苯丙胺（MA--40 mg / kg）的神经毒性方案或其生理盐水载体（对照）对小鼠进行治疗，并在7天时测量纹状体多巴胺（DA）和3,4-二羟基苯乙酸（DOPAC）的水平MA后。生理盐水（对照组）0、1、3妊娠组的纹状体DA，DOPAC和DOPAC / DA比的基础水平相似。与对照组相比，在0和1次妊娠中，对MA的纹状体DA和DOPAC明显降低。妊娠3次的小鼠显示DA和DOPAC的水平与对照组无差异，并且显着高于妊娠0的组。 0个妊娠组的DOPAC / DA比值显着高于所有其他组（对照组，1个和3个妊娠），彼此之间没有差异。这些结果表明，胎次降低MA引起的纹状体多巴胺能神经毒性，并且这种神经保护的程度与经历的怀孕次数有关。

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