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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Contributions of astrocytes to epileptogenesis following status epilepticus: Opportunities for preventive therapy?
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Contributions of astrocytes to epileptogenesis following status epilepticus: Opportunities for preventive therapy?

机译：癫痫持续状态后星形胶质细胞对癫痫发生的贡献：预防性治疗的机会？

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摘要

Status epilepticus (SE) is a life threatening condition that often precedes the development of epilepsy. Traditional treatments for epilepsy have been focused on targeting neuronal mechanisms contributing to hyperexcitability, however, approximately 30% of patients with epilepsy do not respond to existing neurocentric pharmacotherapies. A growing body of evidence has demonstrated that profound changes in the morphology and function of astrocytes accompany SE and persist in epilepsy. Astrocytes are increasingly recognized for their diverse roles in modulating neuronal activity, and understanding the changes in astrocytes following SE could provide important clues about the mechanisms underlying seizure generation and termination. By understanding the contributions of astrocytes to the network changes underlying epileptogenesis and the development of epilepsy, we will gain a greater appreciation of the contributions of astrocytes to dynamic circuit changes, which will enable us to develop more successful therapies to prevent and treat epilepsy. This review summarizes changes in astrocytes following SE in animal models and human temporal lobe epilepsy and addresses the functional consequences of those changes that may provide clues to the process of epileptogenesis.
机译：癫痫持续状态（SE）是一种威胁生命的疾病，通常发生在癫痫发作之前。癫痫病的传统治疗方法集中在靶向促成过度兴奋的神经元机制上，但是，大约30％的癫痫病患者对现有的以神经为中心的药物治疗无效。越来越多的证据表明，星形胶质细胞的形态和功能的深刻变化伴随着SE并持续在癫痫病中。星形胶质细胞因其在调节神经元活动中的不同作用而日益为人们所认识，了解SE后星形胶质细胞的变化可能提供有关癫痫发作产生和终止机制的重要线索。通过了解星形胶质细胞对癫痫发生和癫痫发展背后的网络变化的贡献，我们将更加了解星形胶质细胞对动态电路变化的贡献，这将使我们能够开发出更成功的预防和治疗癫痫的疗法。这篇综述总结了动物模型和人类颞叶癫痫发作后星形胶质细胞的变化，并探讨了这些变化的功能性后果，这些线索可能为癫痫发生过程提供了线索。

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