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首页> 外文期刊>Neurobiology of learning and memory >Hippocampal PKA/CREB pathway is involved in the improvement of memory induced by spermidine in rats.
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Hippocampal PKA/CREB pathway is involved in the improvement of memory induced by spermidine in rats.

机译：海马PKA / CREB通路参与亚精胺诱导的大鼠记忆力的改善。

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摘要

Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D-aspartate (NMDA) receptor function, and has been reported to facilitate memory formation. In the current study we determined whether or not the PKA/CREB signaling pathway is involved in SPD-induced facilitation of memory of inhibitory avoidance task in adult rats. The post-training administration of the cAMP-dependent protein kinase (PKA) inhibitor, N-[2-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide [H-89, 0.5 rhomol intrahippocampal (ih)] or the antagonist of the NMDA receptor polyamine-binding site (arcaine, 0.02 nmol ih) with SPD (0.2 nmol ih) prevented memory improvement induced by SPD. Intrahippocampal administration of SPD (0.2 nmol) facilitated PKA and cAMP response element-binding protein (CREB) phosphorylation in the hippocampus 180 min, but not 30 min, after administration, and increased translocation of the catalytic subunit of PKA into the nucleus. Arcaine (0.02 nmol) and H-89 (0.5 rhomol) prevented the stimulatory effect of SPD on PKA and CREB phosphorylation. These results suggest that memory enhancement induced by the ih administration of SPD involves the PKA/CREB pathways in rats.
机译：亚精胺（SPD）是一种内源性多胺，可调节N-甲基-D-天冬氨酸（NMDA）受体功能，据报道可促进记忆形成。在本研究中，我们确定了PKA / CREB信号通路是否参与SPD诱导的成年大鼠抑制性回避任务记忆的促进。训练后施用cAMP依赖性蛋白激酶（PKA）抑制剂，N- [2-溴肉桂酸氨基）乙基] -5-异喹啉磺酰胺[H-89、0.5 Rhomol海马海马（ih）]或NMDA受体的拮抗剂具有SPD（0.2 nmol ih）的多胺结合位点（arcaine，0.02 nmol ih）阻止了SPD诱导的记忆改善。给药后180分钟（而非30分钟），海马内SPD（0.2 nmol）给药促进了海马中的PKA和cAMP反应元件结合蛋白（CREB）磷酸化，并增加了PKA催化亚基向核内的转运。 Arcaine（0.02 nmol）和H-89（0.5 rhomol）阻止了SPD对PKA和CREB磷酸化的刺激作用。这些结果表明，SPD的ih诱导的记忆增强涉及大鼠的PKA / CREB途径。

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