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首页> 外文期刊>Neurobiology of learning and memory >D-cycloserine facilitates procedural learning but not declarative learning in healthy humans: a randomized controlled trial of the effect of D-cycloserine and valproic acid on overnight properties in the performance of non-emotional memory tasks.
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D-cycloserine facilitates procedural learning but not declarative learning in healthy humans: a randomized controlled trial of the effect of D-cycloserine and valproic acid on overnight properties in the performance of non-emotional memory tasks.

机译：D-环丝氨酸有助于健康人的程序学习，而不是声明式学习：D-环丝氨酸和丙戊酸对非情感性记忆任务执行过程中过夜特性影响的随机对照试验。

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摘要

Although D-cycloserine (DCS), a partial agonist of the N-methyl-d-aspartate (NMDA) receptor, and valproic acid (VPA), a histone deacetylase inhibitor, have been investigated for their roles in the facilitation of emotional learning, the effects on non-emotional declarative and procedural learning have not been clarified. We performed a randomized, blind, placebo-controlled, 4-arm clinical trial to determine the effects of DCS and VPA on the overnight properties of declarative and procedural learning in 60 healthy adults. Subjects were orally administrated a placebo, 100 mg DCS, 400 mg VPA, or a combination of 100 mg DCS and 400 mg VPA before they performed declarative and procedural learning tasks. Subjects then had their performance retested the following day. We observed that DCS facilitated procedural but not declarative learning and that VPA did not contribute to learning. Surprisingly, however, VPA attenuated the enhancement effect of DCS when coadministered with it. These results suggest that DCS acts as an enhancer of hippocampus-independent learning and that VPA may have an extinguishing pharmacological effect on excitatory post-synaptic action potentials that NMDA receptors regulate within procedural learning.
机译：尽管已研究了N-甲基-d-天冬氨酸（NMDA）受体的部分激动剂D-环丝氨酸（DCS）和组蛋白脱乙酰基酶抑制剂丙戊酸（VPA）在促进情绪学习中的作用，对非情感性陈述式和程序性学习的影响尚不清楚。我们进行了一项随机，盲目，安慰剂对照的4臂临床试验，以确定DCS和VPA对60名健康成年人的宣告性和程序性学习的过夜特性的影响。在执行陈述性和程序性学习任务之前，对受试者口服安慰剂，100 mg DCS，400 mg VPA或100 mg DCS和400 mg VPA的组合。然后在第二天对受试者的表现进行了重新测试。我们观察到DCS促进了程序学习而非声明性学习，并且VPA并没有促进学习。然而，令人惊讶的是，当与VPA并用时，VPA减弱了DCS的增强作用。这些结果表明，DCS可作为海马独立学习的增强剂，并且VPA可能对程序性学习中NMDA受体调节的兴奋性突触后动作电位具有药理作用。

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