• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuropharmacology >Valproic acid but not D-cycloserine facilitates sleep-dependent offline learning of extinction and habituation of conditioned fear in humans
【24h】

Valproic acid but not D-cycloserine facilitates sleep-dependent offline learning of extinction and habituation of conditioned fear in humans

机译：丙戊酸而不是D-环丝氨酸有助于人类依赖睡眠的脱机学习灭绝和适应人类的条件性恐惧

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effectiveness of d-cycloserine (DCS), an N-methyl-d-aspartate glutamate receptor partial agonist, and valproic acid (VPA), a histone deacetylase inhibitor, in facilitating the extinction of fear-conditioned memory has been explored in humans and animals. Here, we confirmed whether DCS (100 mg) and VPA (400 mg) act in off-line learning processes during sleep or waking, for further clinical application to anxiety disorders and posttraumatic stress disorder (PTSD). We performed a randomized, blind, placebo-controlled clinical trial in 90 healthy adults. Visual cues and electric shocks were used as the conditioned stimulus (CS) and unconditioned stimulus (US), respectively. The extinction effect was observed not in simple recall after the extinction of coupled CS-US, but was observed in the post-re-exposure phase after unexpected re-exposure to reinstatement CS-US coupling. Newly acquired conditioned fear was also eliminated or habituated by DCS and VPA administration, in line with previous findings. Furthermore, VPA facilitated the off-line learning process of conditioned fear extinction and habituation during sleep, while DCS facilitated this process during waking. These novel findings suggest that DCS and VPA might enhance exposure-based cognitive therapy for anxiety disorders and PTSD by reducing the vulnerability to reinstatement and preventing relapses of fear-conditioned responses, and provide evidence for a peculiarity of the sleep-dependent off-line learning process for conditioned fear extinction. This article is part of a Special Issue entitled 'Cognitive Enhancers'.
机译：人们已经探索了D-环丝氨酸（DCS）（一种N-甲基-d-天冬氨酸谷氨酸受体部分激动剂）和丙戊酸（VPA）（一种组蛋白脱乙酰基酶抑制剂）在促进恐惧条件性记忆消失中的功效，并且动物。在这里，我们确认了DCS（100 mg）和VPA（400 mg）是否在睡眠或醒来的离线学习过程中起作用，以进一步应用于焦虑症和创伤后应激障碍（PTSD）。我们对90名健康成年人进行了一项随机，盲目，安慰剂对照的临床试验。视觉提示和电击分别用作条件刺激（CS）和非条件刺激（US）。在偶联的CS-US灭绝后没有在简单的召回中观察到灭绝效果，而是在意外的再次暴露于CS-US偶联后的再暴露后阶段观察到了灭绝效果。与以前的发现一致，DCS和VPA管理也消除或习惯了新获得的条件性恐惧。此外，VPA促进了睡眠中条件性恐惧消退和习惯化的离线学习过程，而DCS则在清醒过程中促进了这一过程。这些新发现表明，DCS和VPA可能通过减少恢复的脆弱性和防止恐惧条件反应的复发而增强针对焦虑症和PTSD的基于暴露的认知疗法，并为依赖睡眠的离线学习提供独特的证据有条件的恐惧消亡的过程。本文是名为“认知增强器”的特刊的一部分。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号