Using dna methylation to understand biological consequences of genetic variability

HernandezD.G.; SingletonA.B.

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Using dna methylation to understand biological consequences of genetic variability

机译：使用dna甲基化了解遗传变异的生物学后果

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The advent of high-content genomic mapping technologies has provided numerous clues about the genetic architecture of complex disease and the tools with which to understand the biological framework resulting from this architecture. We believe that understanding and mapping epigenetic marks, in particular DNA methylation, which is suited to such assays, offers a timely opportunity in this context. Here, we make an argument for this work, describing this opportunity, the likely path ahead, and the problems and pitfalls associated with such work.

机译：高含量基因组作图技术的出现为复杂疾病的遗传结构提供了许多线索，并为了解这种结构产生的生物学框架提供了工具。我们相信，适合这种检测的表观遗传标记，特别是DNA甲基化的理解和作图，在这种情况下提供了及时的机会。在这里，我们对这项工作进行论证，描述了这种机会，前进的可能路径以及与这项工作相关的问题和陷阱。

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《Neuro-degenerative diseases》 |2012年第2期|共7页
作者
HernandezD.G.; SingletonA.B.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Genetic variability; Genome-wide association; Methylation; Quantitative trait loci;

机译：遗传变异;全基因组关联;甲基化;数量性状位点;

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1. Using dna methylation to understand biological consequences of genetic variability [J] . HernandezD.G., SingletonA.B. Neuro-degenerative diseases . 2012,第2期

机译：使用dna甲基化了解遗传变异的生物学后果
2. Epigenetic consequences of foreign DNA insertions: de novo methylation and global alterations of methylation patterns in recipient genomes. [J] . Doerfler W Reviews in medical virology . 2011,第6期

机译：外源DNA插入的表观遗传学后果：从头甲基化和受体基因组中甲基化模式的整体改变。
3. Population-level analysis reveals the widespread occurrence and phenotypic consequence of DNA methylation variation not tagged by genetic variation in maize [J] . Jing Xu, Guo Chen, Peter J. Hermanson, Genome Biology . 2019,第1期

机译：人口水平分析揭示了DNA甲基化变异的广泛发生和表型后果，所述DNA甲基化变异未通过玉米遗传变异标记
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. Genetic regulation of epigenetic processes in mouse: DNA methylation and X chromosome inactivation [D] . Calaway, John Douglas 2014

机译：小鼠表观遗传过程的遗传调控：DNA甲基化和X染色体失活
6. Using DNA Methylation to Understand Biological Consequences of Genetic Variability [O] . Dena G. Hernandez, Andrew B. Singleton -1

机译：使用DNA甲基化了解遗传变异的生物学后果
7. Using DNA Methylation to Understand Biological Consequences of Genetic Variability [O] . Dena G. Hernandez, Andrew B. Singleton 2012

机译：使用DNA甲基化以了解遗传变异性的生物学后果

Using dna methylation to understand biological consequences of genetic variability

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