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首页> 外文期刊>Neuro-degenerative diseases >Impact of vitamin D on amyloid precursor protein processing and amyloid-β peptide degradation in alzheimer's disease
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Impact of vitamin D on amyloid precursor protein processing and amyloid-β peptide degradation in alzheimer's disease

机译：维生素D对阿尔茨海默氏病中淀粉样前体蛋白加工和淀粉样β肽降解的影响

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摘要

Ninety percent of the elderly population has a vitamin D hypovitaminosis, and several lines of evidence suggest that there might be a potential causal link between Alzheimer's disease (AD) and a non-sufficient supply with vitamin D. However, the mechanisms linking AD to vitamin D have not been completely understood. The aim of our study is to elucidate the impact of 25(OH) vitamin D3 on amyloid precursor protein processing in mice and N2A cells utilizing very moderate and physiological vitamin D hypovitaminosis in the range of 20-30% compared to wild-type mice. We found that already under such mild conditions, amyloid-β peptide (Aβ) is significantly increased, which is caused by an increased β-secretase activity and BACE1 protein level. Additionally, neprilysin (NEP) expression is downregulated resulting in a decreased NEP activity further enhancing the effect of decreased vitamin D on the Aβ level. In line with the in vivo findings, corresponding effects were found with N2A cells supplemented with 25(OH) vitamin D3. Our results further strengthen the link between AD and vitamin D3 and suggest that supplementation of vitamin D3 might have a beneficial effect in AD prevention.
机译：90％的老年人患有维生素D维生素缺乏症，并且有几条证据表明，阿尔茨海默氏病（AD）与维生素D供应不足之间可能存在因果关系。但是，将AD与维生素联系起来的机制D尚未完全了解。我们研究的目的是阐明25（OH）维生素D3对小鼠和N2A细胞中淀粉样前体蛋白加工的影响，利用野生型小鼠的中度和生理性维生素D维生素缺乏症在20-30％的范围内。我们发现，在这种温和条件下，β-淀粉样肽（Aβ）明显增加，这是由于β-分泌酶活性和BACE1蛋白水平增加所致。此外，中性溶酶（NEP）表达下调，导致NEP活性降低，进一步增强了维生素D降低对Aβ水平的作用。与体内发现一致，补充了25（OH）维生素D3的N2A细胞也发现了相应的作用。我们的结果进一步加强了AD与维生素D3之间的联系，并表明补充维生素D3可能对AD预防具有有益作用。

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