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首页> 外文期刊>Neuromuscular disorders: NMD >Microvessel density in muscles of dogs with golden retriever muscular dystrophy.
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Microvessel density in muscles of dogs with golden retriever muscular dystrophy.

机译：患有金毛猎犬营养不良的犬肌肉中的微血管密度。

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摘要

Due to the abundance of muscle, intravascular administration seems required for efficient gene or cell therapy of muscular dystrophy. Here, we examined the skeletal muscle microvasculature to assess if it is altered with dystrophin deficiency. Image analysis of capillaries was performed in three muscles of one- to ten-month-old golden retriever muscular dystrophy (GRMD) dogs and compared with healthy controls. In the gracilis muscle (and in the biceps brachii muscle) of 4- to 10-month-old GRMD dogs, the microvessel density (445+/-47 microvessels per mm(2)), the capillary to fiber ratio (111+/-26 capillaries per 100 myofibers), and the mean intercapillary distance (49+/-3 microm), were similar in affected and control dogs. The sartorius cranialis muscle in GRMD dogs showed microvessel depletion and increased intercapillary distance, but unaltered capillary to fiber ratio, relative to the controls. The mean diameter of microvessels and the total vascular area were higher in GRMD muscles than in control ones. In severely affected GRMD muscles at 7-10 months of age, fibrosis was associated with decreased microvessel density, increased intercapillary distance and microvessel diameter, but normal capillary to fiber ratio and total vascular area.
机译：由于肌肉的丰度，似乎需要对肌营养不良症进行有效的基因或细胞治疗以进行血管内给药。在这里，我们检查了骨骼肌微脉管系统，以评估其是否因肌营养不良蛋白缺乏症而改变。在1到10个月大的金毛寻回性肌营养不良（GRMD）狗的三块肌肉中进行了毛细管图像分析，并与健康对照组进行了比较。在4至10个月大的GRMD狗的腹肌（以及肱二头肌）中，微血管密度（445 +/- 47微血管/ mm（2）），毛细管与纤维的比率（111 + /每100条肌纤维有-26个毛细血管）和平均毛细血管间距离（49 +/- 3微米）在患病和对照犬中相似。相对于对照组，GRMD狗的缝线肌显示出微血管耗竭和毛细血管间距离增加，但毛细血管纤维比率未改变。 GRMD肌肉的微血管平均直径和总血管面积均高于对照组。在7-10个月大的受严重影响的GRMD肌肉中，纤维化与微血管密度降低，毛细血管间距离和微血管直径增加，毛细血管纤维比率和总血管面积正常有关。

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