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首页> 外文期刊>Neuromuscular disorders: NMD >Canine inflammatory myopathy associated with Leishmania Infantum infection.
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Canine inflammatory myopathy associated with Leishmania Infantum infection.

机译：犬利什曼原虫感染相关的犬炎性肌病。

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Inflammatory myopathy associated with several infectious diseases occurs in dogs including those caused by Toxoplasma gondii, Neospora caninum, Ehrlichia canis and Hepatozoon canis. However, muscle disease due to Leishmania infection has been poorly documented. The aim of this study was to examine the distribution and types of cellular infiltrates and expression of MHC class I and II in muscle biopsies obtained from 15 male beagle dogs from a breeder group with an established diagnosis of leishmaniasis. Myopathic features were characterized by necrosis, regeneration, fibrosis and infiltration of mononuclear inflammatory cells consisting of lymphocytes, plasma cells and histiocytes. The predominant leukocyte populations were CD3+, CD8+ and CD45RA+ with lesser numbers of CD4+ cells. Many muscle fibers had MHC class I and II positivity on the sarcolemma. There was a direct correlation between the severity of pathological changes, clinical signs, and the numbers of Leishmania amastigotes. Our studies provided evidence that: 1) Leishmania should be considered as a cause of IM in dogs; 2) Leishmania is not present within muscle fibers but in macrophages, and that 3) the muscle damage might be related to immunological alterations associated with Leishmania infection. Leishmania spp. should also be considered as a possible cause in the pathogenesis of human myositis.
机译：与几种传染病相关的炎性肌病发生在犬中，包括由弓形虫，犬新孢子虫，犬埃里希氏菌和犬肝炎犬引起的犬。但是，由于利什曼原虫感染引起的肌肉疾病的文献报道很少。这项研究的目的是检查从15只雄性比格犬的活检组织中获得的肌肉活检的细胞浸润的分布和类型以及MHC I类和II类的表达，并确定对利什曼病的诊断。肌病的特征是由淋巴细胞，浆细胞和组织细胞组成的单核炎性细胞坏死，再生，纤维化和浸润。主要的白细胞群为CD3 +，CD8 +和CD45RA +，而CD4 +细胞的数量较少。许多肌纤维在肌膜上都具有MHC I级和II级阳性。病理变化的严重程度，临床体征与利什曼原虫的数量之间存在直接的相关性。我们的研究提供了以下证据：1）利什曼原虫应被视为狗中IM的病因; 2）利什曼原虫不存在于肌肉纤维内而是存在于巨噬细胞中，并且3）肌肉损伤可能与与利什曼原虫感染相关的免疫学改变有关。利什曼原虫属也应被认为是人类肌炎发病机理的可能原因。

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