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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Phagocytic properties in tumor astrocytes
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Phagocytic properties in tumor astrocytes

机译：肿瘤星形胶质细胞的吞噬特性

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摘要

In glioblastoma multiforme (GBM), the pathophysiological events preceding and promoting an uncontrolled and remarkable growth is largely unknown. Studies on gliomas and macrophage expression have shown high levels of phagocytic cells, that is, microglial cells. It has also been demonstrated that human astrocytic cells and rat glioma cells are capable of phagocytosis. The purpose of this study was to investigate a potential phagocytic property in human GBM cells in tumor biopsies from surgery. With an immunhistochemical double staining using macrophage markers (CD68 and CD163) and human telomerase reverse transcriptase (hTERT) as a marker for neoplastic cells, we found high levels of double positive cells in human GBM. In hematoxylin-erythrosin stained sections, we also identified fragmented cell components in the cytoplasm of tumor cells. In our judgement, many neoplastic cells in GBM are also positive for macrophage markers. We suggest that human astroglial tumor cells may have phagocytic properties or phagocyte-like properties. This may represent a latent capacity of self-defence, evoked under certain circumstances. It is likely that these properties substantially help the tumors thrive and expand.
机译：在多形性胶质母细胞瘤（GBM）中，在病理生理事件发生之前和促进其不受控制的显着增长是非常未知的。对神经胶质瘤和巨噬细胞表达的研究显示出高水平的吞噬细胞，即小神经胶质细胞。还已经证明人星形细胞和大鼠神经胶质瘤细胞具有吞噬作用。这项研究的目的是研究手术切除的肿瘤活检组织中人GBM细胞的潜在吞噬特性。使用巨噬细胞标记物（CD68和CD163）和人端粒酶逆转录酶（hTERT）作为肿瘤细胞标记物的免疫组织化学双重染色，我们发现人GBM中高水平的双重阳性细胞。在苏木精-赤藓红染色的切片中，我们还确定了肿瘤细胞胞质中的碎片细胞成分。根据我们的判断，GBM中的许多肿瘤细胞对巨噬细胞标记物也呈阳性。我们建议人类星形胶质瘤细胞可能具有吞噬特性或吞噬细胞样特性。在某些情况下，这可能表示潜在的自卫能力。这些特性可能会大大帮助肿瘤the壮成长。

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