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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Lewy body-related alpha-synucleinopathy in the spinal cord of cases with incidental Lewy body disease.
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Lewy body-related alpha-synucleinopathy in the spinal cord of cases with incidental Lewy body disease.

机译：伴有路易体病的患者脊髓中与路易体相关的α-突触核蛋白病。

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摘要

Incidental Lewy body disease (ILBD) represents the early asymptomatic phase of Lewy body diseases (LBD), including idiopathic Parkinson's disease (PD). Although pathological disturbances in the spinal cord, which connects the brain to the peripheral nervous system, plays an important role, the pathology of ILBD has not been adequately examined. Eighteen ILBD and eight age-matched LBD cases were enrolled in the present study. LB-related pathology was immunohistochemically evaluated using anti-phosphorylated alpha-synuclein (palphaSyn) antibodies, revealing LB-related pathology in the spinal cords of 15 (83.3%) of the ILBD cases. Attempts were made to identify the early pattern of palphaSyn deposition in the spinal cord by comparing the cervical, thoracic, lumbar and sacral segments in detail. Most palphaSyn-positive structures were distributed in and around the autonomic nuclei of the spinal cord. The intermediolateral nuclei in the thoracic segments (Th/IML) were the most frequently and severely affected region, suggesting that Th/IML are the first structures affected. Furthermore, following analysis of the distribution pattern of the palphaSyn-positive structures, it is suspected that LB-related pathology progresses toward the caudal vertebrae by involving neurons in the spinal cord that are vulnerable to alphaSyn. It should be noted that the ILBD cases enrolled in the present study were in an earlier stage than the PD cases enrolled in the previous study, and that the present study provides new, previously undescribed information.
机译：偶然的路易体病（ILBD）代表路易体病（LBD）的早期无症状阶段，包括特发性帕金森氏病（PD）。尽管将大脑与周围神经系统连接起来的脊髓病理性疾病起着重要的作用，但ILBD的病理学尚未得到充分检查。本研究共纳入18例ILBD和8例年龄相匹配的LBD病例。使用抗磷酸化的α-突触核蛋白（palphaSyn）抗体对LB相关的病理进行了免疫组织化学评估，揭示了15例ILBD病例中脊髓中的LB相关病理（83.3％）。试图通过详细比较颈，胸，腰和节段来确定脊髓中palphaSyn沉积的早期模式。大多数palphaSyn阳性结构分布在脊髓的自主神经核内和周围。胸段（Th / IML）的内侧外侧核是受累最严重的区域，这表明Th / IML是受影响的首批结构。此外，在分析了palphaSyn阳性结构的分布模式之后，怀疑LB相关的病理学是通过牵涉易受alphaSyn感染的脊髓神经元向尾椎发展的。应该注意的是，本研究中纳入的ILBD病例比先前研究中纳入的PD病例处于早期阶段，并且本研究提供了以前未描述的新信息。

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