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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Hyaluronan in intra-operative edema of NF1-associated neurofibromas
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Hyaluronan in intra-operative edema of NF1-associated neurofibromas

机译：透明质酸在与NF1相关的神经纤维瘤的术中水肿中

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摘要

The tumor suppressor disorder neurofibromatosis type 1 (NF1) is associated with development of multiple neurofibromas which may grow intraneurally as plexiform neurofibromas (PNF) or intracutaneously (CNF). Upon surgery neurofibromas may show prominent swelling hindering skin-edge approximation. To assess whether the water binding glycosaminoglycan hyaluronan is involved in intra-operative swelling, 51 neurofibromas from 33 NF1-patients were investigated. Hyaluronan was histologically demonstrated and was quantified by ELISA. Molecular weight of hyaluronan was determined by gel filtration. Further, hyaluronan content was measured in cultivated Schwann cells and fibroblasts. Clinically, 67% of PNF were associated with moderate or severe intra-operative swelling, whereas only 36% of CNF showed this feature. Significantly higher levels of hyaluronan content were found in PNF compared to CNF (P0.05). Mast cell density did not correlate with any of the parameters. Molecular weight of hyaluronan in PNF and CNF ranged from higher than 10 6 Da to approximately 10 5 Da. Fibroblasts produced less hyaluronan than Schwann cells. The findings support the view that hyaluronan plays an important role in intra-operative swelling in neurofibroma surgery.
机译：肿瘤抑制疾病1型神经纤维瘤病（NF1）与多种神经纤维瘤的发展有关，这些神经纤维瘤可能会在神经内生长成丛状神经纤维瘤（PNF）或皮内（CNF）。手术后神经纤维瘤可能显示出明显的肿胀，阻碍了皮肤边缘的逼近。为了评估水结合糖胺聚糖透明质酸是否参与术中肿胀，研究了来自33名NF1患者的51个神经纤维瘤。透明质酸在组织学上得到证实，并通过ELISA定量。透明质酸的分子量通过凝胶过滤确定。此外，在培养的雪旺氏细胞和成纤维细胞中测量透明质酸含量。临床上，有67％的PNF与中度或严重的术中肿胀有关，而只有36％的CNF表现出此特征。与CNF相比，PNF中的透明质酸含量明显更高（P <0.05）。肥大细胞密度与任何参数均不相关。透明质酸在PNF和CNF中的分子量范围从高于10 6 Da到大约10 5 Da。成纤维细胞产生的透明质酸比雪旺细胞少。这些发现支持了透明质酸在神经纤维瘤手术中术中肿胀中起重要作用的观点。

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