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首页> 外文期刊>Neuron >Neural correlates of task switching in prefrontal cortex and primary auditory cortex in a novel stimulus selection task for rodents
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Neural correlates of task switching in prefrontal cortex and primary auditory cortex in a novel stimulus selection task for rodents

机译：啮齿类动物新刺激选择任务中前额叶皮层和主听皮层任务转换的神经相关性

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摘要

Animals can selectively respond to a target sound despite simultaneous distractors, just as humans can respond to one voice at a crowded cocktail party. To investigate the underlying neural mechanisms, we recorded single-unit activity in primary auditory cortex (A1) and medial prefrontal cortex (mPFC) of rats selectively responding to a target sound from a mixture. We found that prestimulus activity in mPFC encoded the selection rule-which sound from the mixture the rat should select. Moreover, electrically disrupting mPFC significantly impaired performance. Surprisingly, prestimulus activity in A1 also encoded selection rule, a cognitive variable typically considered the domain of prefrontal regions. Prestimulus changes correlated with stimulus-evoked changes, but stimulus tuning was not strongly affected. We suggest a model in which anticipatory activation of a specific network of neurons underlies the selection of a sound from a mixture, giving rise to robust and widespread rule encoding in both brain regions.
机译：尽管存在干扰因素，动物仍可以选择性地对目标声音做出反应，就像人类在拥挤的鸡尾酒会上可以对一种声音做出反应一样。为了研究潜在的神经机制，我们在大鼠的主要听觉皮层（A1）和内侧前额叶皮层（mPFC）中记录了选择性响应混合物中目标声音的单单位活动。我们发现，mPFC中的前刺激活动编码了选择规则-从大鼠应选择的混合物中发出声音。此外，电中断mPFC会严重损害性能。令人惊讶的是，A1中的前刺激活动也编码选择规则，这是一个通常被认为是前额叶区域的认知变量。刺激前的变化与刺激引起的变化相关，但是刺激的调整并没有受到很大的影响。我们建议一种模型，在该模型中，特定神经元网络的预期激活会成为从混合物中选择声音的基础，这会在两个大脑区域产生强大而广泛的规则编码。

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