Selective replenishment of two vesicle pools depends on the source of Ca2+ at the Drosophila synapse.

Kuromi H; Kidokoro Y

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Selective replenishment of two vesicle pools depends on the source of Ca2+ at the Drosophila synapse.

机译：两个囊泡池的选择性补给取决于果蝇突触中Ca2 +的来源。

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After synaptic vesicles (SVs) undergo exocytosis, SV pools are replenished by recycling SVs at nerve terminals. At Drosophila neuromuscular synapses, there are two distinct SV pools (i.e., the exo/endo cycling pool (ECP), which primarily maintains synaptic transmission, and the reserve pool (RP), which participates in synaptic transmission only during tetanic stimulation). Labeling endocytosed vesicular structures with a fluorescent styryl dye, FM1-43, and measuring intracellular Ca2+ concentrations with a Ca2+ indicator, rhod-2, we show here that the ECP is replenished by SVs endocytosed during stimulation, and this process depends on external Ca2+. In contrast, the RP is refilled after cessation of tetanus by a process mediated by Ca2+ released from internal stores.

机译：突触小泡（SV）经历胞吐作用后，通过在神经末梢回收SV来补充SV池。果蝇神经肌肉突触处有两个不同的SV池（即主要维持突触传递的exo / endo循环池（ECP）和仅在强直性刺激期间参与突触传递的储备池（RP））。用荧光苯乙烯基染料FM1-43标记内吞的囊泡结构，并用Ca2 +指示剂rhod-2测量细胞内Ca2 +浓度，我们在这里表明，在刺激过程中被内吞的SV补充了ECP，这个过程取决于外部Ca2 +。相反，在破伤风停止后，RP由内部存储释放的Ca2 +介导的过程重新填充。

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《Neuron》 |2002年第2期|共11页
作者
Kuromi H; Kidokoro Y;
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正文语种 eng
中图分类神经生理学;
关键词
Calcium Signaling; Drosophila melanogaster; Endocytosis; Neuromuscular Junction; 钙信号; 果蝇; 黑腹; 细胞内摄作用; 神经肌肉接头; 突触前末梢; 突触传递; 突触小泡;

机译：Calcium Signaling;Drosophila melanogaster;Endocytosis;Neuromuscular Junction;钙信号;果蝇;黑腹;细胞内摄作用;神经肌肉接头;突触前末梢;突触传递;突触小泡;

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专利

1. Selective replenishment of two vesicle pools depends on the source of Ca2+ at the Drosophila synapse. [J] . Kuromi H, Kidokoro Y Neuron . 2002,第2期

机译：两个囊泡池的选择性补给取决于果蝇突触中Ca2 +的来源。
2. Presynaptic capacitance measurements and Ca2+ uncaging reveal submillisecond exocytosis kinetics and characterize the Ca2+ sensitivity of vesicle pool depletion at a fast CNS synapse. [J] . Wolfel M, Schneggenburger R The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2003,第18期

机译：突触前电容测量和Ca2 +解笼揭示了亚毫秒级胞吐动力学，并表征了CNS突触时囊泡池耗竭的Ca2 +敏感性。
3. Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses [J] . Nicolas Michalski, Juan D Goutman, Sarah Marie Auclair, eLife journal . 2017,第13期

机译：Otoferlin充当Ca2 +传感器，用于听性毛细胞带状突触中的囊泡融合和囊泡池补充
4. Optimal pricing and replenishment policies when consumer demand depends on the in-store inventory level [C] . Jorgensen, S., Kort, Decision and Control, 2000. Proceedings of the 39th IEEE Conference on . 2000

机译：当消费者需求取决于店内库存水平时的最优定价和补货政策
5. Depletion and Replenishment: Exploring Self-Regulation Resource Depletion, Activities that Replenish the Resource, and the Corresponding Effects on Mood. [D] . Klaphake, Sara L. 2011

机译：消耗和补给：探索自我调节资源的消耗，补充资源的活动以及对情绪的相应影响。
6. Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses [O] . Nicolas Michalski, Juan D Goutman, Sarah Marie Auclair, 2017

机译：Otoferlin充当Ca2 +传感器用于听毛细胞带状突触的囊泡融合和囊泡池补充
7. Selective Replenishment of Two Vesicle Pools Depends on the Source of Ca2+ at the Drosophila Synapse [O] . Kuromi Hiroshi, Kidokoro Yoshiaki 2002

机译：两个囊泡池的选择性补给取决于果蝇突触中Ca2 +的来源。

Selective replenishment of two vesicle pools depends on the source of Ca2+ at the Drosophila synapse.

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