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首页> 外文期刊>Neuron >Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system.
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Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system.

机译：果蝇神经肽Y样系统对觅食和社交行为的发育控制。

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摘要

Animals display stereotyped behavioral modifications during development, but little is known about how genes and neural circuits are regulated to turn on/off behaviors. Here we report that Drosophila neuropeptide F (dNPF), a human NPY homolog, coordinates larval behavioral changes during development. The brain expression of npf is high in larvae attracted to food, whereas its downregulation coincides with the onset of behaviors of older larvae, including food aversion, hypermobility, and cooperative burrowing. Loss of dNPF signaling in young transgenic larvae led to the premature display of behavioral phenotypes associated with older larvae. Conversely, dNPF overexpression in older larvae prolonged feeding, and suppressed hypermobility and cooperative burrowing behaviors. The dNPF system provides a new paradigm for studying the central control of cooperative behavior.
机译：动物在发育过程中表现出定型的行为改变，但对如何调节基因和神经回路以开启/关闭行为知之甚少。在这里我们报告果蝇神经肽F（dNPF），人类NPY同源物，协调发育过程中的幼虫行为变化。 npf的大脑表达在被食物吸引的幼虫中较高，而其下调与年龄较大的幼虫的行为相吻合，包括食物厌恶，活动过度和协作挖洞。 dNPF信号在年轻的转基因幼虫中丢失导致与较早的幼虫相关的行为表型过早显示。相反，dNPF在大龄幼虫中的过度表达延长了喂养时间，并抑制了过度活动和协作挖地行为。 dNPF系统为研究合作行为的集中控制提供了新的范例。

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