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Laser ablations reveal functional relationships of segmental hindbrain neurons in zebrafish.

机译:激光消融揭示了斑马鱼中节后脑神经元的功能关系。

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摘要

Segmentation of the vertebrate brain is most obvious in the hindbrain, where successive segments contain repeated neuronal types. One such set of three repeated reticulospinal neurons--the Mauthner cell, MiD2cm, and MiD3cm--is thought to produce different forms of the escape response that fish use to avoid predators. We used laser ablations in larval zebrafish to test the hypothesis that these segmental hindbrain cells form a functional group. Killing all three cells eliminated short-latency, high-performance escape responses to both head- and tail-directed stimuli. Killing just the Mauthner cell affected escapes from tail-directed but not from head-directed stimuli. These results reveal the contributions of one set of reticulospinal neurons to behavior and support the idea that serially repeated hindbrain neurons form functional groups.
机译:脊椎动物脑的分割在后脑中最为明显,其中连续的节段包含重复的神经元类型。这样的一组三个重复的网状脊髓神经元-Mauthner细胞,MiD2cm和MiD3cm-被认为会产生不同形式的逃避反应,鱼类可以利用这些逃避反应来避免掠食者。我们在幼虫斑马鱼中使用了激光消融术,以测试这些节段后脑细胞形成一个功能团的假设。杀死所有三个细胞消除了对头部和尾巴定向刺激的短时延,高性能逃逸反应。仅杀死受影响的Mauthner细胞即可从尾巴导向的刺激逃逸,而不能从头部定向的刺激逃逸。这些结果揭示了一组网状脊髓神经元对行为的贡献,并支持连续重复的后脑神经元形成功能组的观点。

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