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首页> 外文期刊>Neuron >Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.
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Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons.

机译：Doublecortin是一种发育受调节的微管相关蛋白，在迁移和分化的神经元中表达。

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Recently, we and others reported that the doublecortin gene is responsible for X-linked lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons. Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neurons, and a strong axonal labeling is observed in differentiating neurons. In cultured neurons, Doublecortin expression is highest in the distal parts of developing processes. We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP. Our data suggest that the cortical dysgeneses associated with the loss of Doublecortin function might result from abnormal cytoskeletal dynamics in neuronal cell development.
机译：最近，我们和其他人报道说，双皮质素基因负责X连锁的脑小脑和皮层下层状异位症。在这里，我们显示了双皮质素在整个皮质发生过程中的迁移和分化神经元的大脑中表达。免疫组织化学研究表明其定位在躯体和切向迁移神经元的主要过程中，并且在分化的神经元中观察到了强烈的轴突标记。在培养的神经元中，Doublecortin表达在发育过程的远端最高。我们通过沉积和显微镜研究证明Doublecortin与微管（MTs）有关，并假定它是一种新型的MAP。我们的数据表明与Doublecortin功能丧失相关的皮层发育不全可能是由于神经元细胞发育中异常的细胞骨架动力学引起的。

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