• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Eosinophilic intracytoplasmic inclusions in Purkinje neurons of children.
【24h】

Eosinophilic intracytoplasmic inclusions in Purkinje neurons of children.

机译：儿童浦肯野神经元的嗜酸性胞浆内包涵体。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Eosinophilic intracytoplasmic inclusions have been rarely described in Purkinje neurons of children with a variety of neurological conditions. Here we document these inclusions in five children from 3 to 14 years of age. One child had 7q deletion syndrome and a second had profound motor and cognitive delay ("cerebral palsy") of unknown origin, while three others were neurologically normal prior to death. These inclusions stain with the PAS method, are not strongly ubiquitinated, and are located in the lumen of endoplasmic reticulum. Their appearance in a wide range of disorders and in neurologically normal children suggests that they are a nonspecific protein trafficking anomaly, possibly aggravated under degenerative conditions.
机译：在患有多种神经系统疾病的儿童的浦肯野神经元中，很少描述嗜酸性的胞浆内包涵体。在这里，我们记录了5个3至14岁儿童中的夹杂物。一个孩子患有7q缺失综合征，第二个孩子有来历不明的严重运动和认知延迟（“脑瘫”），而其他三个孩子在死亡前神经系统正常。这些内含物用PAS方法染色，没有强烈泛素化，位于内质网腔内。它们在各种疾病和神经系统正常儿童中的出现表明它们是一种非特异性的蛋白质运输异常，在变性条件下可能会加剧。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号