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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Reduced WWOX protein expression in human astrocytoma.
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Reduced WWOX protein expression in human astrocytoma.

机译：在人类星形细胞瘤中WWOX蛋白表达降低。

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摘要

The WW domain-containing oxidoreductase (WWOX) functions as a tumor suppressor by interacting with various proteins in numerous important signaling pathways. WWOX silencing via homozygous deletion of its locus and/or promoter hypermethylation has been observed in various human cancers. However, the relationship between WWOX and tumors in the central nervous system has not been fully explored. In this study, the expression levels of WWOX protein in astrocytomas from 38 patients with different tumor grades were retrospectively analyzed by immunohistochemical staining. The results showed that 19 (50.0%) samples had highly reduced WWOX protein expression when compared with normal controls, while 14 (36.8%) and five (13.2%) cases exhibited moderate and mild decreases in WWOX expression, respectively. Reduction of the expression of WWOX protein correlated with patient age, supra-tentorial localization of the tumor and severity of the symptoms. Furthermore, loss of WWOX expression inversely correlated with survival time. No significant correlation was observed between the loss of WWOX expression and the gender of patients or the difference in pre-operative and post-operative karnofsky performance status scores. Surprisingly, there was no significant correlation between the loss of WWOX protein expression and overall tumor grades. Nevertheless, it was found that 63.6% (7/11) of the grade II astrocytomas had highly reduced WWOX expression and 36.4% (4/11) showed moderately reduced WWOX expression, while none of the samples exhibited mild reductions. Similar results were also found in grade III astrocytomas. The results from this small-size sample pilot study suggest that the loss of WWOX expression may be an early event in the pathogenesis of human astrocytoma.
机译：含WW域的氧化还原酶（WWOX）通过与许多重要信号通路中的各种蛋白质相互作用而起到抑癌作用。在各种人类癌症中已经观察到通过其基因座的纯合缺失和/或启动子高甲基化而使WWOX沉默。但是，WWOX与中枢神经系统肿瘤之间的关系尚未得到充分探讨。在这项研究中，回顾性分析了38例不同肿瘤级别患者星形细胞瘤中WWOX蛋白的表达水平。结果显示，与正常对照组相比，有19个样本（50.0％）的WWOX蛋白表达大大降低，而14个样本（36.8％）和5个样本（13.2％）的WWOX表达分别下降了中度和中度。 WWOX蛋白表达的减少与患者年龄，肿瘤的上膜上定位和症状的严重程度有关。此外，WWOX表达的丧失与生存时间成反比。 WWOX表达的丧失与患者的性别或术前和术后卡诺夫斯基表现状态评分的差异之间未发现显着相关性。令人惊讶的是，WWOX蛋白表达的丧失与总体肿瘤分级之间没有显着相关性。尽管如此，发现有63.6％（7/11）的II级星形细胞瘤高度降低了WWOX表达，而36.4％（4/11）的WWOX表达则有中等程度的降低，而所有样品均未显示出轻度降低。在III级星形细胞瘤中也发现了类似的结果。这项小型样本初步研究的结果表明，WWOX表达的丧失可能是人类星形细胞瘤发病机制中的早期事件。

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