Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system.

Clandinin TR; Lee CH; Herman T; Lee RC; Yang AY; Ovasapyan S; Zipursky SL

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Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system.

机译：果蝇LAR调节视觉系统中的R1-R6和R7目标特异性。

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Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye connect to specific targets in the optic lobe. Using a behavioral screen, we identified LAR, a receptor tyrosine phosphatase, as being required for R cell target specificity. In LAR mutant mosaic eyes, R1-R6 cells target to the lamina correctly, but fail to choose the correct pattern of target neurons. Although mutant R7 axons initially project to the correct layer of the medulla, they retract into inappropriate layers. Using single cell mosaics, we demonstrate that LAR controls targeting of R1-R6 and R7 in a cell-autonomous fashion. The phenotypes of LAR mutant R cells are strikingly similar to those seen in N-cadherin mutants.

机译：果蝇复眼中的不同类别的感光神经元（R细胞）连接到视球中的特定目标。使用行为筛选，我们确定了LAR，受体酪氨酸磷酸酶，是R细胞靶标特异性所必需的。在LAR突变体镶嵌眼中，R1-R6细胞正确地靶向了椎板，但未能选择正确的靶神经元模式。尽管突变体R7轴突最初投射到延髓的正确层，但它们缩回了不适当的层。使用单细胞镶嵌，我们证明了LAR以细胞自主方式控制了针对R1-R6和R7的靶向。 LAR突变体R细胞的表型与N-钙粘蛋白突变体中的表型极为相似。

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《Neuron》 |2001年第2期|共12页
作者
Clandinin TR; Lee CH; Herman T; Lee RC; Yang AY; Ovasapyan S; Zipursky SL;
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正文语种 eng
中图分类神经生理学;
关键词
Drosophila; Photoreceptors; Invertebrate; Receptors; Cell Surface; Visual Pathways; 果蝇属; 光感受器; 无脊椎动物; 受体; 细胞表面; 视通路;

机译：Drosophila;Photoreceptors;Invertebrate;Receptors;Cell Surface;Visual Pathways;果蝇属;光感受器;无脊椎动物;受体;细胞表面;视通路;

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1. Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system. [J] . Clandinin TR, Lee CH, Herman T, Neuron . 2001,第2期

机译：果蝇LAR调节视觉系统中的R1-R6和R7目标特异性。
2. N-cadherin regulates target specificity in the Drosophila visual system. [J] . Lee CH, Herman T, Clandinin TR, Neuron . 2001,第2期

机译：N-钙粘蛋白调节果蝇视觉系统中的靶标特异性。
3. DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. [J] . Sato M, Umetsu D, Murakami S, Nature neuroscience . 2006,第1期

机译：DWnt4调节果蝇视觉系统中视网膜投影的背腹特异性。
4. Dört Kanatlı İnsansız Hava Araçları İçin Yapay Sinir Ağları İle Konum Tabanlı Görsel Servolama Position Based Visual Servoing with Artificial Neural Networks for Quadrotor-type Unmanned Aerial Vehicles [C] . Aybüke Ünlü, Tolga Yüksel Signal Processing and Communications Applications Conference . 2021

机译：基于四翼无人的空气工具基于Visual Servolama位置的视觉伺服与人工神经网络与人工神经网络用于四轮流型无人驾驶飞行器
5. Classical cadherins and target selection in the Drosophila visual system. [D] . Prakash, Saurabh. 2009

机译：果蝇视觉系统中的经典钙黏着蛋白和靶标选择。
6. From the Cover: An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting [O] . Aljoscha Nern, Louis-Vu T. Nguyen, Tory Herman, 2005

机译：从封面开始：果蝇N-钙粘着蛋白的同工型特异性等位基因破坏了R7靶向的后期步骤
7. Drosophila LAR Regulates R1-R6 and R7 Target Specificity in the Visual System [O] . Clandinin Thomas R., Lee Chi-Hon, Herman Tory, 2001

机译：果蝇LAR调节视觉系统中的R1-R6和R7目标特异性

Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system.

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