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首页> 外文期刊>Neuron >Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy.
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Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy.

机译：人类的恐惧条件：意识和自主唤醒对功能神经解剖学的影响。

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摘要

The degree to which perceptual awareness of threat stimuli and bodily states of arousal modulates neural activity associated with fear conditioning is unknown. We used functional magnetic neuroimaging (fMRI) to study healthy subjects and patients with peripheral autonomic denervation to examine how the expression of conditioning-related activity is modulated by stimulus awareness and autonomic arousal. In controls, enhanced amygdala activity was evident during conditioning to both "seen" (unmasked) and "unseen" (backward masked) stimuli, whereas insula activity was modulated by perceptual awareness of a threat stimulus. Absent peripheral autonomic arousal, in patients with autonomic denervation, was associated with decreased conditioning-related activity in insula and amygdala. The findings indicate that the expression of conditioning-related neural activity is modulated by both awareness and representations of bodily states of autonomic arousal.
机译：对威胁刺激和身体觉醒状态的知觉感知调节与恐惧条件相关的神经活动的程度尚不清楚。我们使用功能性磁神经成像（fMRI）研究健康受试者和周围神经自主神经失调的患者，以检查刺激意识和自主神经刺激如何调节与调节有关的活动。在对照组中，杏仁核活动在“看见”（未遮盖）和“看不见”（向后遮盖）刺激条件下均明显增强，而岛突活动受威胁刺激的知觉调节。自主神经支配患者缺乏自主神经引起的自主神经刺激，其与岛上和杏仁核中与调节相关的活动减少。这些发现表明，与调节有关的神经活动的表达受自主觉醒的身体状态的感知和表征所调节。

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