A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis.

Bello BC; Hirth F; Gould AP

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A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis.

机译：果蝇Hox蛋白Abdominal-A的脉冲通过神经母细胞凋亡来调度神经增殖的结束。

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Postembryonic neuroblasts are stem cell-like precursors that generate most neurons of the adult Drosophila central nervous system (CNS). Their capacity to divide is modulated along the anterior-posterior body axis, but the mechanism underlying this is unclear. We use clonal analysis of identified precursors in the abdomen to show that neuron production stops because the cell death program is activated in the neuroblast while it is still engaged in the cell cycle. A burst of expression of the Hox protein Abdominal-A (AbdA) specifies the time at which apoptosis occurs, thereby determining the final number of progeny that each neuroblast generates. These studies identify a mechanism linking the Hox axial patterning system to neural proliferation, and this involves temporal regulation of precursor cell death rather than the cell cycle.

机译：胚后神经母细胞是干细胞样前体，可生成果蝇中枢神经系统（CNS）的大多数神经元。它们的分裂能力沿前后轴调节，但其机制尚不清楚。我们使用已鉴定的腹部前体的克隆分析来显示神经元的生产停止，因为细胞死亡程序在成神经细胞中仍处于细胞周期中被激活。 Hox蛋白Abdominal-A（AbdA）的表达爆发指定了发生凋亡的时间，从而确定了每个成神经细胞生成的后代的最终数量。这些研究确定了将Hox轴向模式系统与神经增殖联系起来的机制，这涉及前体细胞死亡而不是细胞周期的时间调控。

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《Neuron》 |2003年第2期|共11页
作者
Bello BC; Hirth F; Gould AP;
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正文语种 eng
中图分类神经生理学;
关键词
Apoptosis; Drosophila; Drosophila Proteins physiology; Nerve Tissue Proteins; 脱噬作用; 果蝇属; 神经组织蛋白质类; 神经元;

机译：Apoptosis;Drosophila;Drosophila Proteins physiology;Nerve Tissue Proteins;脱噬作用;果蝇属;神经组织蛋白质类;神经元;

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1. A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis. [J] . Bello BC, Hirth F, Gould AP Neuron . 2003,第2期

机译：果蝇Hox蛋白Abdominal-A的脉冲通过神经母细胞凋亡来调度神经增殖的结束。
2. The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain [J] . Heinrich Reichert, Philipp A. Kuert, Bruno C. Bello Biology Open . 2012,第10期

机译：在果蝇脑的胚胎后发育过程中，需要唇酸基因来终止已鉴定的神经母细胞的增殖。在果蝇脑的胚胎后发育过程中，需使用唇唇基因来终止已鉴定的神经母细胞的增殖。果蝇大脑
3. The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel. [J] . Lovato TL, Nguyen TP, Molina MR, Development . 2002,第21期

机译：Hox基因abdominal-A指定果蝇背血管中的心脏细胞命运。
4. Effects of adsorbed proteins, an antifouling agent and long-duration DC voltage pulses on the impedance of silicon-based neural microelectrodes [C] . Salah Sommakia, Jenna L. Rickus, Kevin J. Otto Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2009

机译：吸附蛋白质，防污剂和长持续时间直流电压脉冲对基于硅基神经微电极的阻抗的影响
5. Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes. [O] . F Casares, M Calleja, E Sánchez-Herrero 1996

机译：附体规格中的功能相似性是由超胸腔和腹A果蝇HOX基因引起的。
6. A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis [O] . Bello, B C, Hirth, F, Gould, A P 2003

机译：果蝇Hox蛋白Abdominal-A的脉冲通过神经母细胞凋亡来调度神经增殖的结束

A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis.

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