Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport.

Szebenyi G; Morfini GA; Babcock A; Gould M; Selkoe K; Stenoien DL; Young M; Faber PW; MacDonald ME; McPhaul MJ; Brady ST

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Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport.

机译：亨廷顿蛋白和雄激素受体的神经致病形式抑制了轴突的快速运输。

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Huntington's and Kennedy's disease are autosomal dominant neurodegenerative diseases caused by pathogenic expansion of polyglutamine tracts. Expansion of glutamine repeats must in some way confer a gain of pathological function that disrupts an essential cellular process and leads to loss of affected neurons. Association of huntingtin with vesicular structures raised the possibility that axonal transport might be altered. Here we show that polypeptides containing expanded polyglutamine tracts, but not normal N-terminal huntingtin or androgen receptor, directly inhibit both fast axonal transport in isolated axoplasm and elongation of neuritic processes in intact cells. Effects were greater with truncated polypeptides and occurred without detectable morphological aggregates.

机译：亨廷顿氏病和肯尼迪氏病是由聚谷氨酰胺束的致病性扩张引起的常染色体显性遗传神经退行性疾病。谷氨酰胺重复序列的扩增必须以某种方式赋予病理功能，从而破坏必要的细胞过程并导致受影响的神经元丢失。亨廷顿蛋白与水泡结构的联系增加了轴突运输可能改变的可能性。在这里，我们显示了包含扩展的聚谷氨酰胺束，但不包含正常的N末端亨廷顿蛋白或雄激素受体的多肽，直接抑制了离体轴突中的快速轴突运输和完整细胞中神经过程的延长。截短的多肽效果更大，并且在没有可检测的形态聚集体的情况下发生。

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来源
《Neuron》 |2003年第1期|共12页
作者
Szebenyi G; Morfini GA; Babcock A; Gould M; Selkoe K; Stenoien DL; Young M; Faber PW; MacDonald ME; McPhaul MJ; Brady ST;
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正文语种 eng
中图分类基础医学;
关键词
Axonal Transport; Nerve Tissue Proteins; Nuclear Proteins; Receptors; Androgen; 轴突运输; 神经组织蛋白质类; 核蛋白质类; 受体; 雄激素;

机译：Axonal Transport;Nerve Tissue Proteins;Nuclear Proteins;Receptors;Androgen;轴突运输;神经组织蛋白质类;核蛋白质类;受体;雄激素;

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1. Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport. [J] . Szebenyi G, Morfini GA, Babcock A, Neuron . 2003,第1期

机译：亨廷顿蛋白和雄激素受体的神经致病形式抑制了轴突的快速运输。
2. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. [J] . Morfini GA, You YM, Pollema SL Nature neuroscience . 2009,第7期

机译：致病性亨廷顿蛋白通过激活JNK3和磷酸化驱动蛋白来抑制轴突的快速运输。
3. A Yeast Screen System for Aromatase Inhibitors and Ligands for Androgen Receptor: Yeast Cells Transformed with Aromatase and Androgen Receptor [J] . Paul mak, Fernando Dela, Shiuan Chen Environmental Health Perspectives . 1999,第11期

机译：芳香酶抑制剂和雄激素受体配体的酵母筛选系统：转化为芳香酶和雄激素受体的酵母细胞
4. Novel Strategies for Targeting the Androgen-Receptor Axis: PARP1 as a Mediator of Androgen Receptor-Dependent Transcriptional Control [C] . Karen E. Knudsen Genitourinary Cancers Symposium . 2013

机译：靶向雄激素受体轴的新策略：PARP1作为雄激素受体依赖性转录控制的介质
5. Protein inhibitor of activated STAT y (PIASy) in androgen receptor signaling and prostate cancer. [D] . Gross, Mitchell E. 2003

机译：雄激素受体信号转导和前列腺癌中活化STAT y（PIASy）的蛋白抑制剂。
6. Pathogenic Huntingtin Inhibits Fast Axonal Transport by Activating JNK3 and Phosphorylating Kinesin [O] . Gerardo A Morfini, Yi-Mei You, Sarah L Pollema, -1

机译：致病性亨廷顿通过激活JNK3和磷酸化的Kinesin来抑制快速的轴突运输
7. Neuropathogenic Forms of Huntingtin and Androgen Receptor Inhibit Fast Axonal Transport [O] . Szebenyi Györgyi, Morfini Gerardo A., Babcock Alyssa, 2003

机译：Huntingtin和雄激素受体的神经病理学形式抑制轴突的快速运输。

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport.

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