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首页> 外文期刊>Neuron >Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice.
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Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice.

机译：降钙素（orexin）在突触后的单个棘突中诱导钙瞬变，从而在额叶前切片中识别出丘脑皮层。

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In vivo, thalamocortical axons are susceptible to the generation of terminal spikes which antidromically promote bursting in the thalamus. Although neurotransmitters could elicit such ectopic action potentials at thalamocortical boutons, this hypothesis has never been confirmed. Prefrontal cortex is the cortical area most implicated in arousal and is innervated by thalamic neurons that are unusual since they burst rhythmically during waking. We show that a neurotransmitter critical for alertness, hypocretin (orexin), directly excites prefrontal thalamocortical synapses in acute slice. This TTX-sensitive activation of thalamic axons was demonstrated electrophysiologically and by two-photon sampling of calcium transients at single spines in apposition to thalamic boutons anterogradely labeled in vivo. Spines receiving these long-range projections constituted a unique population in terms of the presynaptic excitatory action of hypocretin. By this mechanism, the hypocretin projection to prefrontal cortex may play a larger role in prefrontal or executive anticipated.
机译：在体内，丘脑皮质轴突易受末端刺突的产生，该刺突抗性地促进丘脑的破裂。尽管神经递质可以在丘脑皮层引起这种异位动作电位，但这一假设尚未得到证实。前额叶皮层是最易引起唤醒的皮层区域，并由丘脑神经元神经支配，这是不寻常的，因为它们在醒来时有节奏地破裂。我们表明，对于戒备至关重要的神经递质，降钙素（orexin），直接在急性切片中激发前额丘脑突触。丘脑轴突的这种TTX敏感激活是通过电生理学和通过双光子采样在单个棘突上与体内顺行地标记的丘脑后突结合的钙瞬变来证明的。接受这些远程预测的棘突在促胰液素的突触前兴奋作用方面构成独特的种群。通过这种机制，降肾上腺素投射到前额叶皮层可能在预期的前额叶或执行中发挥更大的作用。

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