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首页> 外文期刊>Neuron >The hippocampal-VTA loop: controlling the entry of information into long-term memory.
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The hippocampal-VTA loop: controlling the entry of information into long-term memory.

机译:海马-VTA回路:控制信息进入长期记忆的过程。

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摘要

In this article we develop the concept that the hippocampus and the midbrain dopaminergic neurons of the ventral tegmental area (VTA) form a functional loop. Activation of the loop begins when the hippocampus detects newly arrived information that is not already stored in its long-term memory. The resulting novelty signal is conveyed through the subiculum, accumbens, and ventral pallidum to the VTA where it contributes (along with salience and goal information) to the novelty-dependent firing of these cells. In the upward arm of the loop, dopamine (DA) is released within the hippocampus; this produces an enhancement of LTP and learning. These findings support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory.
机译:在本文中,我们提出了腹侧被盖区(VTA)的海马和中脑多巴胺能神经元形成功能环的概念。当海马检测到新近到达的信息(尚未存储在其长期记忆中)时,开始激活循环。产生的新奇信号通过下丘,伏隔和腹侧苍白球传送到VTA,在VTA中(与显着性和目标信息一起)有助于这些细胞的新奇依赖性放电。在环的上臂,海马内释放多巴胺(DA);这增强了LTP和学习。这些发现为海马VTA环调节信息进入长期记忆的模型提供了支持。

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