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首页> 外文期刊>Neuron >Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation.
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Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation.

机译：奖励相关的多巴胺能中脑的FMRI激活与增强的海马依赖性长期记忆形成有关。

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摘要

Long-term potentiation in the hippocampus can be enhanced and prolonged by dopaminergic inputs from midbrain structures such as the substantia nigra. This improved synaptic plasticity is hypothesized to be associated with better memory consolidation in the hippocampus. We used a condition that reliably elicits a dopaminergic response, reward anticipation, to study the relationship between activity of dopaminergic midbrain areas and hippocampal long-term memory in healthy adults. Pictures of object drawings that predicted monetary reward were associated with stronger fMRI activity in reward-related brain areas, including the substantia nigra, compared with non-reward-predicting pictures. Three weeks later, recollection and source memory were better for reward-predicting than for non-reward-predicting pictures. FMRI activity in the hippocampus and the midbrain was higher for reward-predicting pictures that were later recognized compared with later forgotten pictures. These data are consistent with the hypothesis that activation of dopaminergic midbrain regions enhances hippocampus-dependent memory formation, possibly by enhancing consolidation.
机译：来自中脑结构（如黑质）的多巴胺能输入可增强和延长海马的长期增强作用。据推测，这种改善的突触可塑性与海马中更好的记忆巩固有关。我们使用一种能够可靠引发多巴胺能反应，奖励预期的条件来研究健康成年人中多巴胺能中脑区活动与海马长期记忆之间的关系。与非奖励图片相比，预测金钱奖励的对象图纸图片与奖励相关的大脑区域（包括黑质）的功能磁共振成像活动更强。三个星期后，对于奖励预测而言，回忆和源记忆要比对非奖励图片要好。与后来被遗忘的图片相比，后来被识别的奖励预测图片在海马和中脑的FMRI活动更高。这些数据与多巴胺能中脑区域的激活可能通过增强巩固来增强海马依赖性记忆形成的假设相一致。

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