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首页> 外文期刊>Neuron >Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.
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Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.

机译：自发性视网膜活动介导v1中眼优势柱和双眼感受野的发育。

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The mechanisms that give rise to ocular dominance columns (ODCs) during development are controversial. Early experiments indicated a key role for retinal activity in ODC formation. However, later studies showed that in those early experiments, the retinal activity perturbation was initiated after ODCs had already formed. Moreover, recent studies concluded that early eye removals do not impact ODC segregation. Here we blocked spontaneous retinal activity during the very early stages of ODC development. This permanently disrupted the anatomical organization of ODCs and led to a dramatic increase in receptive field size for binocular cells in primary visual cortex. Our data suggest that early spontaneous retinal activity conveys crucial information about whether thalamocortical axons represent one or the other eye and that this activity mediates binocular competition important for shaping receptive fields in primary visual cortex.
机译：在发育过程中引起眼优势柱（ODC）的机制是有争议的。早期实验表明视网膜活性在ODC形成中起关键作用。但是，后来的研究表明，在那些早期的实验中，视网膜活性扰动是在ODCs形成后开始的。此外，最近的研究得出的结论是，早期摘除眼球不会影响ODC隔离。在这里，我们在ODC发展的早期阶段阻止了自发性视网膜活动。这永久性地破坏了ODCs的解剖结构，并导致初级视觉皮层中双眼细胞的感受野大小急剧增加。我们的数据表明，早期的自发性视网膜活动传达了有关丘脑皮层轴突代表一只眼睛还是另一只眼睛的重要信息，并且该活动介导了对形成初级视皮层感受野至关重要的双目竞争。

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