nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory.

DeZazzo J; Sandstrom D; de Belle-S; Velinzon K; Smith P; Grady L; DelVecchio M; Ramaswami M; Tully T

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nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory.

机译：果蝇，果蝇myb相关Adf1转录因子的突变，破坏突触的形成和嗅觉记忆。

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nalyot (nal) is a novel olfactory memory mutant of Drosophila, encoding Adf1, a myb-related transcription factor. Following extended training sessions, Adf1 mutants show normal early memory but defective longterm memory. Adf1 shows widespread spatiotemporal expression, yet mutant alleles reveal no discernible disruptions in gross morphology of the nervous system. Studies at the larval neuromuscular junction, however, reveal a role for Adf1 in the modulation of synaptic growth-in contrast to the role established for dCREB2 in the control of synaptic function (Davis et al., 1996). These findings suggest that Adf1 and dCREB2 regulate distinct transcriptional cascades involved in terminal stages of synapse maturation. More generally, Adf1 provides a novel link between molecular mechanisms of developmental and behavioral plasticity.

机译：Nalyot（nal）是果蝇的一种新型嗅觉记忆突变体，编码与Myb相关的转录因子Adf1。经过延长的培训课程，Adf1突变体显示正常的早期记忆但长期记忆缺陷。 Adf1显示广泛的时空表达，但突变等位基因显示神经系统的总体形态没有明显的破坏。然而，在幼虫神经肌肉接头处的研究表明，Adf1在调节突触生长中起着作用-与dCREB2在控制突触功能中所起的作用相反（Davis等，1996）。这些发现表明Adf1和dCREB2调节参与突触成熟末期的独特转录级联反应。更一般而言，Adf1在发育和行为可塑性的分子机制之间提供了新颖的联系。

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《Neuron》 |2000年第1期|共14页
作者
DeZazzo J; Sandstrom D; de Belle-S; Velinzon K; Smith P; Grady L; DelVecchio M; Ramaswami M; Tully T;
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正文语种 eng
中图分类神经生理学;
关键词
Genes; myb genetics; Insect Proteins; Memory; Mutation; Smell; Synapses; 昆虫蛋白质类; 记忆; 突变; 嗅觉; 突触; 转录因子;

机译：Genes;myb genetics;Insect Proteins;Memory;Mutation;Smell;Synapses;昆虫蛋白质类;记忆;突变;嗅觉;突触;转录因子;

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1. nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory. [J] . DeZazzo J, Sandstrom D, de Belle-S, Neuron . 2000,第1期

机译：果蝇，果蝇myb相关Adf1转录因子的突变，破坏突触的形成和嗅觉记忆。
2. Mutations in the Transcription Elongation Factor SPT5 Disrupt a Reporter for Dosage Compensation in Drosophila [J] . Mahalakshmi Prabhakaran, Richard L. Kelley PLoS Genetics . 2012,第11期

机译：转录延伸因子SPT5中的突变打断了果蝇剂量补偿的记者。
3. Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila [J] . K. VijayRaghavan, Sonia Sen, Heinrich Reichert, Biology Open . 2014,第8期

机译：在果蝇中，嗅觉投射神经元和局部中间神经元的发育需要齿科。在果蝇中，嗅觉投射神经元和局部中间神经元的发育需要齿科
4. Ultrastructral Analysis of Synapse in a Drosophila of the Swedish Mutation Which Causes Early-Onset Alzheimer's Disease Using Focused Ion Beam Microscopy [C] . Se Jin Park, Andreas Schertel, Sung Sik Han International Metallographic Society Annual meeting;Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting . 2011

机译：使用聚焦离子束显微镜在瑞典突变的果蝇中引起早发阿尔茨海默氏病的突触的超微结构分析
5. A mutational and functional analysis of C-terminal sequences of human transcription factor REL: Their role in cellular transformation and transcriptional activation. [D] . Starczynowski, Daniel T. 2006

机译：人类转录因子REL C末端序列的突变和功能分析：它们在细胞转化和转录激活中的作用。
6. The Drosophila Transcription Factor Adf-1 (nalyot) Regulates Dendrite Growth by Controlling FasII and Staufen Expression Downstream of CaMKII and Neural Activity [O] . Christina Timmerman, Somu Suppiah, Baraka V. Gurudatta, 2013

机译：果蝇转录因子Adf-1（nalyot）通过控制CaMKII下游的FasII和Staufen表达以及神经活动来调节树突的生长。
7. nalyot, a Mutation of the Drosophila Myb-Related Adf1 Transcription Factor, Disrupts Synapse Formation and Olfactory Memory [O] . DeZazzo James, Sandstrom David, de Belle Steve, 2000

机译：nalyot，果蝇Myb相关的Adf1转录因子的突变，破坏突触形成和嗅觉记忆。

nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory.

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