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首页> 外文期刊>Neuron >A screen of cell-surface molecules identifies leucine-rich repeat proteins as key mediators of synaptic target selection.
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A screen of cell-surface molecules identifies leucine-rich repeat proteins as key mediators of synaptic target selection.

机译：细胞表面分子的筛选将富含亮氨酸的重复蛋白鉴定为突触靶选择的关键介体。

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In Drosophila embryos and larvae, a small number of identified motor neurons innervate body wall muscles in a highly stereotyped pattern. Although genetic screens have identified many proteins that are required for axon guidance and synaptogenesis in this system, little is known about the mechanisms by which muscle fibers are defined as targets for specific motor axons. To identify potential target labels, we screened 410 genes encoding cell-surface and secreted proteins, searching for those whose overexpression on all muscle fibers causes motor axons to make targeting errors. Thirty such genes were identified, and a number of these were members of a large gene family encoding proteins whose extracellular domains contain leucine-rich repeat (LRR) sequences, which are protein interaction modules. By manipulating gene expression in muscle 12, we showed that four LRR proteins participate in the selection of this muscle as the appropriate synaptic target for the RP5 motor neuron.
机译：在果蝇胚胎和幼虫中，少数已识别的运动神经元以高度定型的方式支配着体壁肌肉。尽管遗传筛查已经确定了该系统中轴突引导和突触形成所需的许多蛋白质，但对于将肌纤维定义为特定运动轴突靶标的机制知之甚少。为了识别潜在的目标标记，我们筛选了410个编码细胞表面和分泌蛋白的基因，寻找那些在所有肌肉纤维上过度表达导致运动轴突产生靶向错误的基因。鉴定了30个这样的基因，其中许多是编码蛋白质的大基因家族的成员，这些蛋白质的胞外域包含富含亮氨酸的重复（LRR）序列，该序列是蛋白质相互作用模块。通过操纵肌肉12中的基因表达，我们显示了四种LRR蛋白参与了该肌肉的选择，作为RP5运动神经元的适当突触靶标。

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